Bianca2012 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen

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Model Identifier
MODEL1907260002
Short description
This model describes the humoral and cellular response of the immune system to a tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The model is used to analyze and investigate the competition between immune system cells and mammary carcinoma cells under the action of a vaccine.
Format
SBML (L2V4)
Related Publication
  • Mathematical modeling of the immune system recognition to mammary carcinoma antigen.
  • Bianca C, Chiacchio F, Pappalardo F, Pennisi M
  • BMC bioinformatics , 1/ 2012 , Volume 13 Suppl 17 , pages: S21 , PubMed ID: 23281916
  • Dipartimento di Matematica e Informatica, Università di Catania, Catania, Italy.
  • The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Johannes Meyer
Modellers: Johannes Meyer

Metadata information

Curation status
Non-curated
Tags
Immuno-oncology

Connected external resources

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Model files
Bianca2012 v7.0.xml SBML L2V4 Representation of Bianca2012 - Mathematical modeling of the immune system recognition to mammary carcinoma antigen 106.33 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Jul 26, 2019 11:40:34 AM
  • Last Modified: Jul 26, 2019 11:40:34 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jul 26, 2019 11:40:34 AM
    • Submitted by: Johannes Meyer
    • With comment: Edited model metadata online.