Susree2017 - Role of platelet count and inhibitors in blood coagulation

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Mathematical model of blood coagulation that incorporates platelet binding sites.
Related Publication
  • A mathematical model for in vitro coagulation of blood: role of platelet count and inhibition
  • M. Susree, M. Anand
  • Sādhanā , 2/ 2017 , Volume 42 , Issue 3 , pages: 291-305 , DOI: 10.1007/s12046-017-0602-3
  • Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, Kandi, Sangareddy, India
  • A mechanistic model including the role of platelets is proposed for clot formation and growth in plasma in vitro. Initiation of clot formation is by the addition of tissue factor, and initiation via the intrinsic pathway is neglected. Activation of zymogens follows the extrinsic pathway cascade and reactions on platelet membranes are included. Platelet activation occurs due to thrombin and also due to other activated platelets. Inhibition of the active clotting factors is by ATIII and TFPI, whereas inhibition due to APC is not relevant in the conditions modeled. The model predictions matched existing data for thrombin production in synthetic plasma. The model predicts that inhibition of platelet-driven activation of platelets has a major effect on concentration of activated platelets in PRP, normal plasma and PPP. Inhibition of platelet activation by (other activated) platelets significantly delays thrombin production in PRP and normal plasma as compared to that by thrombin. Further, sensitivity analysis shows that the model is most sensitive to the activation of platelet membrane-bound factor X by the intrinsic tenase complex.
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

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Gene Ontology blood coagulation

isDescribedBy (1 statement)

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Model files

Susree2017.xml SBML L2V4 representation of Susree2017 - Role of platelet count and inhibitors in blood coagulation 72.81 KB Preview | Download

Additional files

Susree2017.cps Model COPASI file. Author correspondance: k23 = 2.223e-7 (not e-4) and k41 = 147 (not 200). 134.47 KB Preview | Download
fig2.jpg Model simulation result for figure 2 by adjusting initial conditions of ATIII and TFPI with TF = 25pM. Peak values are approximately the same. Time at which peak occurs is late. 16.95 KB Preview | Download
fig3.jpg Model simulation result for figure 3 by adjusting initial conditions of PRO (II, V, VIII, IX, X) and ANTI (ATIII, TFPI) factors with TF = 5pM. 17.88 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Aug 13, 2018 1:35:38 PM
  • Last Modified: Aug 13, 2018 1:35:38 PM
  • Version: 2 public model Download this version
    • Submitted on: Aug 13, 2018 1:35:38 PM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.