Tanos2008 - Blood coagulation and Snake Venom

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Short description
Mathematical model of the blood coagulation cascade including interaction of snake venom and antivenom.
Related Publication
  • A model for venom-induced consumptive coagulopathy in snake bite.
  • Tanos PP, Isbister GK, Lalloo DG, Kirkpatrick CM, Duffull SB
  • Toxicon : official journal of the International Society on Toxinology , 12/ 2008 , Volume 52 , Issue 7 , pages: 769-780 , PubMed ID: 18831981
  • School of Pharmacy, University of Queensland, St. Lucia, QLD 4072, Brisbane, Australia.
  • Many snake venoms contain procoagulant toxins that activate the coagulation cascade and cause venom-induced consumptive coagulopathy (VICC). We developed a semi-mechanistic model of the clotting cascade in order to explore the effects of the procoagulant toxin from taipan venom on this system as well as the effects of antivenom. Simulations of the time course in the change of clotting factors were compared to data collected from taipan envenomed patients. The model accurately predicted the observed concentration of clotting factors over time following taipan envenomation. Investigations from the model indicated that the upper limit of the half-life of the procoagulant toxin was 1h. Simulations from the model also suggest that antivenom for Australasian elapids has negligible effect on reducing the recovery time of the coagulation profile unless administered almost immediately after envenomation. The model has generality to be expanded to describe the effects of other venoms and drugs on the clotting cascade.
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

Metadata information

isDescribedBy (1 statement)
PubMed 18831981

isVersionOf (1 statement)
Gene Ontology blood coagulation

Curation status


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Model files

Tanos2008.xml SBML L2V4 representation of Tanos2008 - Blood coagulation and Snake Venom 112.91 KB Preview | Download

Additional files

Tanos2008.cps Model COPASI file. Typo in XI and XIa ODEs (degradation term involved IX and IXa). Production terms defined in section 2.1.1. dXIII set to 0.05 as explained in the text (2.1.1). Concentrations become negative. May be due to stiffness even with interval size of 1e-5. 184.50 KB Preview | Download
fig3.jpg Attempt at reproducing figure 3. 32.25 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Jun 15, 2018 4:35:03 PM
  • Last Modified: Jun 15, 2018 4:35:03 PM
  • Version: 2 public model Download this version
    • Submitted on: Jun 15, 2018 4:35:03 PM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.