Xu2005 - Blood Coagulation Model of Activated Factors of Extrinsic Pathway and TFPI

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Model Identifier
Short description
System of ODEs to describe the behaviour of the activated factors of the extrinsic pathway of blood coagulation with the addition of the TFPI-Xa complex. Mass-action kinetics used with the only exception of factor IIa production (Michaelis-Menten rate law).
Related Publication
  • Simulation of a mathematical model of the role of the TFPI in the extrinsic pathway of coagulation.
  • Xu C, Hu Xu X, Zeng Y, Wen Chen Y
  • Computers in biology and medicine , 6/ 2005 , Volume 35 , Issue 5 , pages: 435-445 , PubMed ID: 15767116
  • Forensic Department of Shantou Medical College, Shantou University, Shantou 515031, China. xuchuanqing@sina.com
  • Blood coagulation is a complex physiological process. With the development of biochemistry and molecular biology, especially the discovery of the tissue factor pathway inhibitor (TFPI) and further research, the researches of tissue factor (TF) and TFPI have been the hot topics now. Based on this result, we provide a new concept of blood coagulation system and provide a dynamic model to describe the role of TFPI of this pathway. Through stability analysis of the equilibrium point and numerical simulations, we obtain some important conclusions. All these results may have great significance for lesions of cardiac vessels and cerebral vessels, haemophilia, DIC, thrombosis formation and malignancy.
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

Metadata information

isDescribedBy (1 statement)
PubMed 15767116

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology blood coagulation

Curation status


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Model files

Xu2005.xml SBML L2V4 representation of Xu2005 - Blood Coagulation Model of Activated Factors of Extrinsic Pathway and TFPI 14.30 KB Preview | Download

Additional files

Xu2005.cps Noncurated model COPASI file. Model encoded using list of ODEs labelled equation 1. Initial conditions given for zymogens however ODES describe the behaviour of activated factors. 47.32 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Jun 13, 2018 9:28:39 AM
  • Last Modified: Jun 13, 2018 9:28:39 AM
  • Version: 2 public model Download this version
    • Submitted on: Jun 13, 2018 9:28:39 AM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.