Xu2002 - Blood Coagulation Model of Activated Factors with Platelet Activation

  public model
Model Identifier
MODEL1806130001
Short description
System of ODEs to describe the dynamics of several activated factors of blood coagulation. Publication introduces a platelet activation term for synthesis of Xa and IIa.
Format
SBML (L2V4)
Related Publication
  • Dynamic model of the role of platelets in the blood coagulation system.
  • Xu CQ, Zeng YJ, Gregersen H
  • Medical engineering & physics , 11/ 2002 , Volume 24 , Issue 9 , pages: 587-593 , PubMed ID: 12376045
  • Biomechanics Research Center, Beijing Polytechnic University, 100022, Beijing, China.
  • In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model of the function of platelets in blood coagulation is provided based on biochemical experiments. A series of conclusions based on qualitative analysis and mathematical simulation are drawn about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin (IIa). It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade. The value is related to the rate of platelet activation, the binding constant d2. The stability of the fixed value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin. The proportion of platelets activated at any given time is designated c. To each c, we obtain a maximum concentration of thrombin. It is evident that when the level of factor IX is below 1% of normal levels, the rate of thrombin generation reduces dramatically resulting in severe bleeding tendency.
Contributors
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

Metadata information

isDescribedBy (1 statement)
PubMed 12376045

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology blood coagulation

hasPart (1 statement)
Gene Ontology platelet activation

Curation status
Non-curated
Tags

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files
Xu2002.xml SBML L2V4 representation of Xu2002 - Blood Coagulation Model of Activated Factors with Platelet Activation 16.66 KB Preview | Download

Additional files
Xu2002.cps Noncurated model COPASI file. Model encoded using system of ODEs labelled equation 2. Encoded parameter c_0 is fixed but defined as fraction of activated platelets over total platelets. Function f(x4) unknown. Initial conditions given for zymogens however the ODE system describes dynamics of activated factors. 47.00 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Jun 13, 2018 9:18:13 AM
  • Last Modified: Jun 13, 2018 9:18:13 AM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Jun 13, 2018 9:18:13 AM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.