Khanin1998 - Mathematical Model of Blood Coagulation Prothrombin Time Test

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Model Identifier
Short description
Blood coagulation model for prothrombin time test.
Related Publication
  • Mathematical model for the blood coagulation prothrombin time test.
  • Khanin MA, Rakov DV, Kogan AE
  • Thrombosis research , 3/ 1998 , Volume 89 , Issue 5 , pages: 227-232 , PubMed ID: 9645916
  • Laboratory of Theoretical Biology, Russian State University of Technology, Moscow.
  • A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.
Submitter of the first revision: Matthew Roberts
Submitter of this revision: Matthew Roberts
Modellers: Matthew Roberts

Metadata information

isDescribedBy (1 statement)
PubMed 9645916

hasTaxon (1 statement)
Taxonomy Homo sapiens

isVersionOf (1 statement)
Gene Ontology blood coagulation

isPropertyOf (1 statement)

Curation status


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Model files

Khanin1998.xml SBML L2V4 representation of Khanin1998 - Mathematical Model of Blood Coagulation Prothrombin Time Test 44.13 KB Preview | Download

Additional files

Khanin1998.cps Noncurated model COPASI file. Model encoded using reactions in table 1. There appears to be discrepancies between the reactions listed in table 1, the pathway scheme and the example ODE. 122.65 KB Preview | Download

  • Model originally submitted by : Matthew Roberts
  • Submitted: Jun 12, 2018 11:53:39 AM
  • Last Modified: Jun 12, 2018 11:53:39 AM
  • Version: 2 public model Download this version
    • Submitted on: Jun 12, 2018 11:53:39 AM
    • Submitted by: Matthew Roberts
    • With comment: Edited model metadata online.