Martinez-Guimera2017 - Generic negative feedback circuit (Model 4)

  public model
Model Identifier
MODEL1710260003
Short description
Martinez-Guimera2017 - Generic negative feedback circuit (Model 4)

This model is described in the article:

Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP.
Mech. Ageing Dev. 2017 Nov; :

Abstract:

The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation.

This model is hosted on BioModels Database and identified by: MODEL1710260003.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V4)
Related Publication
  • 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.
  • Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP
  • Mechanisms of ageing and development , 1/ 2018 , Volume 169 , pages: 53-62 , PubMed ID: 29146308
  • Institute for Cell and Molecular Biosciences (ICaMB), Ageing Research Laboratories, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL,United Kingdom; MRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), United Kingdom.
  • The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation.
Contributors
Submitter of the first revision: Alvaro Martinez Guimera
Submitter of this revision: Alvaro Martinez Guimera
Modellers: Alvaro Martinez Guimera

Metadata information

is (1 statement)
BioModels Database MODEL1710260003

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Non-curated


Tags

Connected external resources

SBGN view in Newt Editor

Name Description Size Actions

Model files

MODEL1710260003_url.xml SBML L2V4 representation of Martinez-Guimera2017 - Generic negative feedback circuit (Model 4) 22.94 KB Preview | Download

Additional files

MODEL1710260003-biopax2.owl Auto-generated BioPAX (Level 2) 13.15 KB Preview | Download
MODEL1710260003-biopax3.owl Auto-generated BioPAX (Level 3) 23.11 KB Preview | Download
MODEL1710260003.m Auto-generated Octave file 5.14 KB Preview | Download
MODEL1710260003.png Auto-generated Reaction graph (PNG) 57.58 KB Preview | Download
MODEL1710260003.sci Auto-generated Scilab file 67.00 Bytes Preview | Download
MODEL1710260003.svg Auto-generated Reaction graph (SVG) 18.88 KB Preview | Download
MODEL1710260003.vcml Auto-generated VCML file 890.00 Bytes Preview | Download
MODEL1710260003.xpp Auto-generated XPP file 3.06 KB Preview | Download
MODEL1710260003_urn.xml Auto-generated SBML file with URNs 22.95 KB Preview | Download

  • Model originally submitted by : Alvaro Martinez Guimera
  • Submitted: Oct 26, 2017 8:51:11 AM
  • Last Modified: Dec 5, 2017 5:15:47 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Dec 5, 2017 5:15:47 PM
    • Submitted by: Alvaro Martinez Guimera
    • With comment: Current version of MODEL1710260003
  • Version: 1 public model Download this version
    • Submitted on: Oct 26, 2017 8:51:11 AM
    • Submitted by: Alvaro Martinez Guimera
    • With comment: Original import of MODEL1710260003

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.