Tikidji-Hamburyan2018 - Rod phototransduction under strong illumination

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Tikidji-Hamburyan2018 - Rod phototransduction under strong illumination

This model is described in the article:

Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, Münch TA.
Nat Commun 2017 Nov; 8(1): 1813

Abstract:

Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of rod saturation is not well defined; some studies report rod activity well into the photopic range. Using electrophysiological recordings from retina and dorsal lateral geniculate nucleus of cone-deficient and visually intact mice, we describe stimulus and physiological factors that influence photopic rod-driven responses. We find that rod contrast sensitivity is initially strongly reduced at high irradiances, but progressively recovers to allow responses to moderate contrast stimuli. Surprisingly, rods recover faster at higher light levels. A model of rod phototransduction suggests that phototransduction gain adjustments and bleaching adaptation underlie rod recovery. Consistently, exogenous chromophore reduces rod responses at bright background. Thus, bleaching adaptation renders mouse rods responsive to modest contrast at any irradiance. Paradoxically, raising irradiance across the photopic range increases the robustness of rod responses.

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SBML (L2V4)
Related Publication
  • Rods progressively escape saturation to drive visual responses in daylight conditions.
  • Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, Münch TA
  • Nature communications , 11/ 2017 , Volume 8 , Issue 1 , pages: 1813
  • Department of Neurosurgery and Hansen Experimental Physics Laboratory, Stanford University, Stanford, California, 94305-4085, USA.
  • Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of rod saturation is not well defined; some studies report rod activity well into the photopic range. Using electrophysiological recordings from retina and dorsal lateral geniculate nucleus of cone-deficient and visually intact mice, we describe stimulus and physiological factors that influence photopic rod-driven responses. We find that rod contrast sensitivity is initially strongly reduced at high irradiances, but progressively recovers to allow responses to moderate contrast stimuli. Surprisingly, rods recover faster at higher light levels. A model of rod phototransduction suggests that phototransduction gain adjustments and bleaching adaptation underlie rod recovery. Consistently, exogenous chromophore reduces rod responses at bright background. Thus, bleaching adaptation renders mouse rods responsive to modest contrast at any irradiance. Paradoxically, raising irradiance across the photopic range increases the robustness of rod responses.
Contributors
Johannes Dietter

Metadata information

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Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Non-curated
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  • Model originally submitted by : Johannes Dietter
  • Submitted: Oct 3, 2017 1:22:47 AM
  • Last Modified: Apr 30, 2018 12:07:19 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Apr 30, 2018 12:07:19 PM
    • Submitted by: Johannes Dietter
    • With comment: Current version of MODEL1710030000
  • Version: 1 public model Download this version
    • Submitted on: Oct 3, 2017 1:22:47 AM
    • Submitted by: Johannes Dietter
    • With comment: Original import of MODEL1710030000