Uhlén2017 - TCGA-4P-AA8J-01A - Head and Neck Squamous Cell Carcinoma (male, 67 years)

Model Identifier
MODEL1707110790
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 67 years with Head and Neck Squamous Cell Carcinoma affecting the patient's salivary gland.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-4P-AA8J-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110790.

Other models with the same disease include MODEL1707112623 MODEL1707112624 MODEL1707112625 MODEL1707112626 MODEL1707112627 MODEL1707112628 MODEL1707112629 MODEL1707112630 MODEL1707112631 MODEL1707112632 MODEL1707112633 MODEL1707112634 MODEL1707112635 MODEL1707112636 MODEL1707112637 MODEL1707112638 MODEL1707112639 MODEL1707112640 MODEL1707112641 MODEL1707112642 MODEL1707112643 MODEL1707112644 MODEL1707112645 MODEL1707112646 MODEL1707112647 MODEL1707112648 MODEL1707112649 MODEL1707112650 MODEL1707113313 MODEL1707113574 MODEL1707113575 MODEL1707113576 MODEL1707113577 MODEL1707113578 MODEL1707113579 MODEL1707113580 MODEL1707113581 MODEL1707113582 MODEL1707113583 MODEL1707113584 MODEL1707113585 MODEL1707113586 MODEL1707113587 MODEL1707113588 MODEL1707113589 MODEL1707113590 MODEL1707113591 MODEL1707113592 MODEL1707113593 MODEL1707113594 MODEL1707113595 MODEL1707113596 MODEL1707113597 MODEL1707113598 MODEL1707113599 MODEL1707113600 MODEL1707113601 MODEL1707113602 MODEL1707113603 MODEL1707113604 MODEL1707113605 MODEL1707113606 MODEL1707113607 MODEL1707113608 MODEL1707113609 MODEL1707113610 MODEL1707113611 MODEL1707113612 MODEL1707113613 MODEL1707113614 MODEL1707113615 MODEL1707113616 MODEL1707113617 MODEL1707113618 MODEL1707113619 MODEL1707113620 MODEL1707113621 MODEL1707113622 MODEL1707113623 MODEL1707113624 MODEL1707113625 MODEL1707113626 MODEL1707113627 MODEL1707113628 MODEL1707113629 MODEL1707113630 MODEL1707113631 MODEL1707113632 MODEL1707113633 MODEL1707113634 MODEL1707113635 MODEL1707113636 MODEL1707113637 MODEL1707113638 MODEL1707113639 MODEL1707113640 MODEL1707113641 MODEL1707113642 MODEL1707113643 MODEL1707113644 MODEL1707113645 MODEL1707113646 MODEL1707113647 MODEL1707113648 MODEL1707113649 MODEL1707113650 MODEL1707113651 MODEL1707113652 MODEL1707113653 MODEL1707113654 MODEL1707113655 MODEL1707113656 MODEL1707113657 MODEL1707113658 MODEL1707113659 MODEL1707113660 MODEL1707113661 MODEL1707113662 MODEL1707113663 MODEL1707113664 MODEL1707113665 MODEL1707113666 MODEL1707113667 MODEL1707113668 MODEL1707113669 MODEL1707113670 MODEL1707113671 MODEL1707113672 MODEL1707113673 MODEL1707113674 MODEL1707113675 MODEL1707113676 MODEL1707113677 MODEL1707113678 MODEL1707113679 MODEL1707113680 MODEL1707113681 MODEL1707113682 MODEL1707113683 MODEL1707113684 MODEL1707113685 MODEL1707113686 MODEL1707113687 MODEL1707113694 MODEL1707113695 MODEL1707113696 MODEL1707113697 MODEL1707113698 MODEL1707113699 MODEL1707113700 MODEL1707113701 MODEL1707113702 MODEL1707113703 MODEL1707113704 MODEL1707113705 MODEL1707113706 MODEL1707113707 MODEL1707113708 MODEL1707113709 MODEL1707113710 MODEL1707113711 MODEL1707113712 MODEL1707113713 MODEL1707113714 MODEL1707113715 MODEL1707113716 MODEL1707113717 MODEL1707113718 MODEL1707113719 MODEL1707113720 MODEL1707113721 MODEL1707113722 MODEL1707113723 MODEL1707113724 MODEL1707113725 MODEL1707113726 MODEL1707113727 MODEL1707113728 MODEL1707113729 MODEL1707113730 MODEL1707113731 MODEL1707113732 MODEL1707113733 MODEL1707113734 MODEL1707113735 MODEL1707113736 MODEL1707113737 MODEL1707113738 MODEL1707113739 MODEL1707113740 MODEL1707113741 MODEL1707113742 MODEL1707113743 MODEL1707113744 MODEL1707113745 MODEL1707113746 MODEL1707113747 MODEL1707113748 MODEL1707113749 MODEL1707113750 MODEL1707113751 MODEL1707113752 MODEL1707113753 MODEL1707113754 MODEL1707113755 MODEL1707113756 MODEL1707113757 MODEL1707113758 MODEL1707113759 MODEL1707113760 MODEL1707113761 MODEL1707113762 MODEL1707113763 MODEL1707113764 MODEL1707113765 MODEL1707113766 MODEL1707113767 MODEL1707113768 MODEL1707113769 MODEL1707113770 MODEL1707113771 MODEL1707113772 MODEL1707113773 MODEL1707113774 MODEL1707113775 MODEL1707113776 MODEL1707113777 MODEL1707113791 MODEL1707113792 MODEL1707113793 MODEL1707113794 MODEL1707113917 MODEL1707113918 MODEL1707113919 MODEL1707113920 MODEL1707113921 MODEL1707113922 MODEL1707113923 MODEL1707113924 MODEL1707113925 MODEL1707113926 MODEL1707114345 MODEL1707114346 MODEL1707114347 MODEL1707114348 MODEL1707114349 MODEL1707115103 MODEL1707115104 MODEL1707115105 MODEL1707115106 MODEL1707115107 MODEL1707115108 MODEL1707115109 MODEL1707115110 MODEL1707115111 MODEL1707115112 MODEL1707115113 MODEL1707115470 MODEL1707115471 MODEL1707115472 MODEL1707115473 MODEL1707115539 MODEL1707115540 MODEL1707115541 MODEL1707115542 MODEL1707115543 MODEL1707115544 MODEL1707115545 MODEL1707115563 MODEL1707115702 MODEL1707115703 MODEL1707115704 MODEL1707115705 MODEL1707115706 MODEL1707115707 MODEL1707115708 MODEL1707115932 MODEL1707115933 MODEL1707115934 MODEL1707115935 MODEL1707116036 MODEL1707116037 MODEL1707116038 MODEL1707116039 MODEL1707116052 MODEL1707116053 MODEL1707116120 MODEL1707116121 MODEL1707116122 MODEL1707116123 MODEL1707116124 MODEL1707116125 MODEL1707116126 MODEL1707116127 MODEL1707116128 MODEL1707116177 MODEL1707116178 MODEL1707116179 MODEL1707116180 MODEL1707116181 MODEL1707116182 MODEL1707116183 MODEL1707116184 MODEL1707116185 MODEL1707116230 MODEL1707116281 MODEL1707116282 MODEL1707116286 MODEL1707116287 MODEL1707116300 MODEL1707116301 MODEL1707116302 MODEL1707116303 MODEL1707116304 MODEL1707116305 MODEL1707116306 MODEL1707116307 MODEL1707116308 MODEL1707116309 MODEL1707116310 MODEL1707116313 MODEL1707116505 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome. Click here to expand
  • Mathias Uhlen, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma Lundberg, Sophia Hober, Peter Nilsson, Johanna Mattsson, Jochen M Schwenk, Hans Brunnström, Bengt Glimelius, Tobias Sjöblom, Per-Henrik Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoglu, Fredrik Ponten
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , pages: eaan2507 , PubMed ID: 28818916
  • Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1707110790

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (3 statements)
Human Disease Ontology head and neck squamous cell carcinoma
Mathematical Modelling Ontology Constraint-based model
PATO male

isDerivedFrom (2 statements)
Genomic Data Commons Data Portal 757c56d0-8a49-464f-866a-ae98816de60b
BioModels Database MODEL1402200003

Curation status
Non-curated
Tags
Auto-Generated

Connected external resources