Model Identifier
MODEL1707110789
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 68 years with Colon Adenocarcinoma affecting the patient's colon and rectum.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-4N-A93T-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110789.

Other models with the same disease include MODEL1707110792 MODEL1707110978 MODEL1707110979 MODEL1707110980 MODEL1707111621 MODEL1707111622 MODEL1707111623 MODEL1707111624 MODEL1707111625 MODEL1707111626 MODEL1707111627 MODEL1707111628 MODEL1707111629 MODEL1707111630 MODEL1707111631 MODEL1707111632 MODEL1707111633 MODEL1707111634 MODEL1707111635 MODEL1707111636 MODEL1707111637 MODEL1707111638 MODEL1707111639 MODEL1707111640 MODEL1707111641 MODEL1707111642 MODEL1707111643 MODEL1707111644 MODEL1707111645 MODEL1707111646 MODEL1707111647 MODEL1707111648 MODEL1707111649 MODEL1707111650 MODEL1707111651 MODEL1707111652 MODEL1707111653 MODEL1707111654 MODEL1707111655 MODEL1707111656 MODEL1707111657 MODEL1707111658 MODEL1707111659 MODEL1707111660 MODEL1707111661 MODEL1707111662 MODEL1707111663 MODEL1707111664 MODEL1707111761 MODEL1707111762 MODEL1707111763 MODEL1707111764 MODEL1707111765 MODEL1707111766 MODEL1707111767 MODEL1707111768 MODEL1707111769 MODEL1707111770 MODEL1707111771 MODEL1707111772 MODEL1707111773 MODEL1707111774 MODEL1707111775 MODEL1707111776 MODEL1707111777 MODEL1707111778 MODEL1707111779 MODEL1707111780 MODEL1707111781 MODEL1707111782 MODEL1707111783 MODEL1707111784 MODEL1707111785 MODEL1707111786 MODEL1707111787 MODEL1707111788 MODEL1707111789 MODEL1707111790 MODEL1707111791 MODEL1707111792 MODEL1707111793 MODEL1707111794 MODEL1707111795 MODEL1707111796 MODEL1707111797 MODEL1707111798 MODEL1707111799 MODEL1707111800 MODEL1707111801 MODEL1707111802 MODEL1707111803 MODEL1707111804 MODEL1707111805 MODEL1707111806 MODEL1707111807 MODEL1707111808 MODEL1707111809 MODEL1707111810 MODEL1707111811 MODEL1707111812 MODEL1707111813 MODEL1707111814 MODEL1707111815 MODEL1707111816 MODEL1707111817 MODEL1707111818 MODEL1707111819 MODEL1707111820 MODEL1707111821 MODEL1707111822 MODEL1707111823 MODEL1707111824 MODEL1707111825 MODEL1707111826 MODEL1707111827 MODEL1707111828 MODEL1707111829 MODEL1707111830 MODEL1707111831 MODEL1707111832 MODEL1707111833 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MODEL1707114330 MODEL1707114331 MODEL1707114332 MODEL1707114333 MODEL1707114334 MODEL1707114335 MODEL1707114336 MODEL1707114337 MODEL1707114338 MODEL1707114339 MODEL1707114340 MODEL1707114341 MODEL1707114342 MODEL1707115083 MODEL1707115084 MODEL1707115085 MODEL1707115086 MODEL1707115087 MODEL1707115088 MODEL1707115089 MODEL1707115090 MODEL1707115091 MODEL1707115092 MODEL1707115093 MODEL1707115094 MODEL1707115306 MODEL1707115307 MODEL1707115308 MODEL1707115309 MODEL1707115310 MODEL1707115311 MODEL1707115312 MODEL1707115313 MODEL1707115314 MODEL1707115315 MODEL1707115316 MODEL1707115317 MODEL1707115318 MODEL1707115319 MODEL1707115320 MODEL1707115321 MODEL1707115322 MODEL1707115323 MODEL1707115324 MODEL1707115325 MODEL1707115326 MODEL1707115327 MODEL1707115328 MODEL1707116067 MODEL1707116068 MODEL1707116069 MODEL1707116070 MODEL1707116071 MODEL1707116072 MODEL1707116073 MODEL1707116074 MODEL1707116172 MODEL1707116173 MODEL1707116174 MODEL1707116175 MODEL1707116176 MODEL1707116186 MODEL1707116231 MODEL1707116260 MODEL1707116284 MODEL1707116513 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome. Click here to expand
  • Mathias Uhlen, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma Lundberg, Sophia Hober, Peter Nilsson, Johanna Mattsson, Jochen M Schwenk, Hans Brunnström, Bengt Glimelius, Tobias Sjöblom, Per-Henrik Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoglu, Fredrik Ponten
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , pages: eaan2507 , PubMed ID: 28818916
  • Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu
Curator: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1707110789

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (3 statements)
Human Disease Ontology colon adenocarcinoma
Mathematical Modelling Ontology Constraint-based model
PATO male

isDerivedFrom (2 statements)
Genomic Data Commons Data Portal 92554413-9ebc-4354-8e1b-9682f3a031d9
BioModels Database MODEL1402200003

Curation status
Non-curated
Tags
Auto-Generated

Connected external resources