Model Identifier
MODEL1707110690
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 70 years with Kidney Renal Clear Cell Carcinoma affecting the patient's kidney.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-3Z-A93Z-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110690.

Other models with the same disease include MODEL1707111510 MODEL1707111511 MODEL1707111512 MODEL1707111513 MODEL1707111514 MODEL1707111515 MODEL1707111516 MODEL1707111517 MODEL1707111518 MODEL1707111519 MODEL1707111520 MODEL1707111521 MODEL1707111522 MODEL1707111523 MODEL1707111524 MODEL1707111525 MODEL1707111526 MODEL1707111527 MODEL1707111528 MODEL1707111529 MODEL1707111530 MODEL1707111531 MODEL1707111532 MODEL1707111533 MODEL1707111534 MODEL1707111535 MODEL1707111536 MODEL1707111537 MODEL1707111538 MODEL1707111539 MODEL1707111540 MODEL1707111541 MODEL1707111542 MODEL1707111543 MODEL1707111544 MODEL1707111545 MODEL1707111546 MODEL1707111547 MODEL1707111548 MODEL1707111549 MODEL1707111550 MODEL1707111551 MODEL1707111552 MODEL1707111553 MODEL1707111554 MODEL1707111555 MODEL1707111556 MODEL1707111557 MODEL1707112060 MODEL1707112061 MODEL1707112062 MODEL1707112063 MODEL1707112064 MODEL1707112065 MODEL1707112066 MODEL1707112067 MODEL1707112068 MODEL1707112069 MODEL1707112070 MODEL1707112071 MODEL1707112072 MODEL1707112073 MODEL1707112074 MODEL1707112075 MODEL1707112076 MODEL1707112077 MODEL1707112078 MODEL1707112079 MODEL1707112080 MODEL1707112262 MODEL1707112263 MODEL1707112345 MODEL1707112346 MODEL1707112347 MODEL1707112348 MODEL1707112349 MODEL1707112350 MODEL1707112351 MODEL1707112352 MODEL1707112353 MODEL1707112354 MODEL1707112355 MODEL1707112356 MODEL1707112357 MODEL1707112358 MODEL1707112359 MODEL1707112360 MODEL1707112361 MODEL1707112362 MODEL1707112363 MODEL1707112364 MODEL1707112365 MODEL1707112366 MODEL1707112367 MODEL1707112368 MODEL1707112369 MODEL1707112370 MODEL1707112371 MODEL1707112372 MODEL1707112373 MODEL1707112374 MODEL1707112375 MODEL1707112376 MODEL1707112377 MODEL1707112378 MODEL1707112379 MODEL1707112380 MODEL1707112381 MODEL1707112382 MODEL1707112383 MODEL1707112384 MODEL1707112385 MODEL1707112386 MODEL1707112387 MODEL1707112388 MODEL1707112389 MODEL1707112390 MODEL1707112391 MODEL1707112392 MODEL1707112393 MODEL1707112394 MODEL1707112395 MODEL1707112396 MODEL1707112397 MODEL1707112398 MODEL1707112399 MODEL1707112400 MODEL1707112401 MODEL1707112402 MODEL1707112403 MODEL1707112404 MODEL1707112405 MODEL1707112406 MODEL1707112407 MODEL1707112408 MODEL1707112409 MODEL1707112410 MODEL1707112411 MODEL1707112412 MODEL1707112413 MODEL1707112414 MODEL1707112415 MODEL1707112416 MODEL1707112417 MODEL1707112418 MODEL1707112419 MODEL1707112420 MODEL1707112421 MODEL1707112422 MODEL1707112423 MODEL1707112424 MODEL1707112425 MODEL1707112426 MODEL1707112427 MODEL1707112428 MODEL1707112429 MODEL1707112430 MODEL1707112431 MODEL1707112432 MODEL1707112433 MODEL1707112434 MODEL1707112435 MODEL1707112436 MODEL1707112437 MODEL1707112438 MODEL1707112439 MODEL1707112440 MODEL1707112441 MODEL1707112451 MODEL1707112452 MODEL1707112453 MODEL1707112454 MODEL1707112455 MODEL1707112456 MODEL1707112457 MODEL1707112458 MODEL1707112459 MODEL1707112460 MODEL1707112461 MODEL1707112462 MODEL1707112466 MODEL1707112467 MODEL1707112468 MODEL1707112469 MODEL1707112470 MODEL1707112471 MODEL1707112472 MODEL1707112473 MODEL1707112474 MODEL1707112581 MODEL1707112582 MODEL1707112583 MODEL1707112584 MODEL1707112585 MODEL1707112586 MODEL1707112587 MODEL1707112588 MODEL1707112589 MODEL1707112590 MODEL1707112591 MODEL1707112592 MODEL1707112593 MODEL1707112594 MODEL1707112595 MODEL1707112596 MODEL1707112597 MODEL1707112598 MODEL1707112599 MODEL1707112600 MODEL1707112601 MODEL1707112602 MODEL1707112603 MODEL1707112604 MODEL1707112605 MODEL1707112606 MODEL1707112607 MODEL1707112608 MODEL1707112609 MODEL1707112610 MODEL1707112923 MODEL1707112924 MODEL1707112925 MODEL1707112926 MODEL1707112927 MODEL1707112928 MODEL1707112929 MODEL1707112930 MODEL1707112931 MODEL1707112932 MODEL1707112933 MODEL1707112934 MODEL1707112935 MODEL1707112936 MODEL1707112937 MODEL1707112938 MODEL1707112939 MODEL1707112940 MODEL1707112941 MODEL1707112942 MODEL1707112943 MODEL1707112944 MODEL1707112945 MODEL1707112946 MODEL1707112947 MODEL1707112948 MODEL1707112949 MODEL1707112950 MODEL1707112951 MODEL1707112952 MODEL1707112953 MODEL1707112954 MODEL1707112955 MODEL1707112956 MODEL1707112957 MODEL1707112958 MODEL1707112959 MODEL1707112960 MODEL1707112961 MODEL1707112962 MODEL1707112963 MODEL1707112964 MODEL1707112965 MODEL1707112966 MODEL1707112967 MODEL1707112968 MODEL1707112969 MODEL1707112970 MODEL1707112971 MODEL1707112972 MODEL1707112973 MODEL1707112974 MODEL1707112975 MODEL1707112976 MODEL1707112977 MODEL1707112978 MODEL1707112979 MODEL1707112980 MODEL1707112981 MODEL1707112982 MODEL1707112983 MODEL1707112984 MODEL1707112985 MODEL1707112986 MODEL1707112987 MODEL1707112988 MODEL1707112989 MODEL1707112990 MODEL1707112991 MODEL1707112992 MODEL1707112993 MODEL1707112994 MODEL1707112995 MODEL1707112996 MODEL1707112997 MODEL1707112998 MODEL1707112999 MODEL1707113000 MODEL1707113001 MODEL1707113002 MODEL1707113003 MODEL1707113004 MODEL1707113005 MODEL1707113006 MODEL1707113007 MODEL1707113008 MODEL1707113009 MODEL1707113010 MODEL1707113011 MODEL1707113012 MODEL1707113013 MODEL1707113014 MODEL1707113015 MODEL1707113016 MODEL1707113017 MODEL1707113018 MODEL1707113019 MODEL1707113020 MODEL1707113021 MODEL1707113022 MODEL1707113023 MODEL1707113024 MODEL1707113025 MODEL1707113026 MODEL1707113027 MODEL1707113028 MODEL1707113029 MODEL1707113030 MODEL1707113031 MODEL1707113032 MODEL1707113033 MODEL1707113034 MODEL1707113035 MODEL1707113036 MODEL1707113037 MODEL1707113038 MODEL1707113039 MODEL1707113040 MODEL1707113041 MODEL1707113042 MODEL1707113043 MODEL1707113044 MODEL1707113045 MODEL1707113046 MODEL1707113047 MODEL1707113048 MODEL1707113049 MODEL1707113050 MODEL1707113051 MODEL1707113464 MODEL1707113465 MODEL1707113466 MODEL1707113467 MODEL1707113468 MODEL1707113469 MODEL1707113470 MODEL1707113471 MODEL1707113472 MODEL1707113473 MODEL1707113474 MODEL1707113475 MODEL1707113476 MODEL1707113477 MODEL1707113478 MODEL1707113479 MODEL1707113480 MODEL1707113481 MODEL1707113482 MODEL1707113483 MODEL1707113484 MODEL1707113485 MODEL1707113486 MODEL1707113487 MODEL1707113488 MODEL1707113489 MODEL1707113490 MODEL1707113491 MODEL1707113492 MODEL1707113493 MODEL1707113494 MODEL1707113495 MODEL1707113496 MODEL1707113497 MODEL1707113498 MODEL1707113499 MODEL1707113500 MODEL1707113501 MODEL1707113502 MODEL1707113503 MODEL1707113504 MODEL1707113505 MODEL1707113506 MODEL1707113507 MODEL1707113508 MODEL1707113509 MODEL1707113510 MODEL1707113511 MODEL1707113512 MODEL1707113513 MODEL1707113514 MODEL1707113515 MODEL1707113516 MODEL1707113517 MODEL1707113518 MODEL1707113519 MODEL1707113520 MODEL1707113521 MODEL1707113522 MODEL1707113523 MODEL1707113524 MODEL1707113525 MODEL1707113526 MODEL1707113527 MODEL1707113778 MODEL1707113779 MODEL1707113780 MODEL1707113781 MODEL1707113782 MODEL1707113783 MODEL1707113784 MODEL1707113785 MODEL1707113786 MODEL1707113787 MODEL1707113788 MODEL1707113789 MODEL1707113790 MODEL1707113795 MODEL1707113796 MODEL1707113797 MODEL1707113798 MODEL1707113799 MODEL1707113800 MODEL1707113801 MODEL1707113802 MODEL1707113803 MODEL1707113804 MODEL1707113805 MODEL1707113806 MODEL1707113807 MODEL1707113808 MODEL1707113809 MODEL1707113810 MODEL1707113811 MODEL1707113812 MODEL1707113813 MODEL1707113814 MODEL1707113815 MODEL1707113816 MODEL1707113817 MODEL1707113818 MODEL1707113819 MODEL1707113820 MODEL1707113821 MODEL1707113822 MODEL1707113823 MODEL1707113824 MODEL1707113825 MODEL1707113826 MODEL1707113827 MODEL1707113828 MODEL1707114365 MODEL1707114366 MODEL1707114367 MODEL1707114368 MODEL1707114369 MODEL1707114370 MODEL1707114371 MODEL1707114372 MODEL1707114373 MODEL1707114374 MODEL1707114375 MODEL1707114376 MODEL1707114992 MODEL1707114993 MODEL1707114994 MODEL1707114995 MODEL1707115332 MODEL1707115333 MODEL1707115334 MODEL1707115335 MODEL1707115412 MODEL1707116016 MODEL1707116017 MODEL1707116044 MODEL1707116283 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome. Click here to expand
  • Mathias Uhlen, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma Lundberg, Sophia Hober, Peter Nilsson, Johanna Mattsson, Jochen M Schwenk, Hans Brunnström, Bengt Glimelius, Tobias Sjöblom, Per-Henrik Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoglu, Fredrik Ponten
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , pages: eaan2507 , PubMed ID: 28818916
  • Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu
Curator: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1707110690

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (3 statements)
Human Disease Ontology renal clear cell carcinoma
Mathematical Modelling Ontology Constraint-based model
PATO male

isDerivedFrom (2 statements)
Genomic Data Commons Data Portal 2b1dea0a-6d55-4fdd-9c1c-0d9fbe03bd78
BioModels Database MODEL1402200003

Curation status
Non-curated
Tags
Auto-Generated

Connected external resources