Model Identifier
MODEL1707110430
Short description

This is a whole genome metabolism model of a male patient diagnosed at the age of 52 years with Prostate Adenocarcinoma affecting the patient's prostate.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-2A-A8VL-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110430.

Other models with the same disease include MODEL1707110431 MODEL1707110432 MODEL1707110433 MODEL1707110434 MODEL1707110435 MODEL1707110436 MODEL1707110437 MODEL1707110438 MODEL1707110439 MODEL1707110788 MODEL1707113426 MODEL1707113427 MODEL1707113428 MODEL1707113429 MODEL1707113430 MODEL1707113431 MODEL1707113432 MODEL1707113433 MODEL1707113434 MODEL1707113435 MODEL1707113436 MODEL1707113437 MODEL1707113438 MODEL1707113439 MODEL1707113440 MODEL1707113441 MODEL1707113442 MODEL1707113443 MODEL1707113444 MODEL1707113445 MODEL1707113446 MODEL1707113447 MODEL1707113448 MODEL1707113449 MODEL1707113450 MODEL1707113451 MODEL1707113452 MODEL1707113453 MODEL1707113454 MODEL1707113455 MODEL1707113456 MODEL1707113457 MODEL1707114669 MODEL1707114670 MODEL1707114671 MODEL1707114672 MODEL1707114673 MODEL1707114674 MODEL1707114675 MODEL1707114676 MODEL1707114677 MODEL1707114678 MODEL1707114679 MODEL1707114680 MODEL1707114681 MODEL1707114682 MODEL1707114683 MODEL1707114684 MODEL1707114685 MODEL1707114686 MODEL1707114687 MODEL1707114688 MODEL1707114689 MODEL1707114690 MODEL1707114691 MODEL1707114692 MODEL1707114693 MODEL1707114694 MODEL1707114695 MODEL1707114696 MODEL1707114697 MODEL1707114698 MODEL1707114699 MODEL1707114700 MODEL1707114701 MODEL1707114702 MODEL1707114703 MODEL1707114704 MODEL1707114705 MODEL1707114706 MODEL1707114707 MODEL1707114708 MODEL1707114709 MODEL1707114710 MODEL1707114711 MODEL1707114712 MODEL1707114713 MODEL1707114714 MODEL1707114715 MODEL1707114716 MODEL1707114717 MODEL1707114718 MODEL1707114719 MODEL1707114720 MODEL1707114721 MODEL1707114722 MODEL1707114723 MODEL1707114724 MODEL1707114725 MODEL1707114726 MODEL1707114727 MODEL1707114728 MODEL1707114729 MODEL1707114730 MODEL1707114731 MODEL1707114732 MODEL1707114733 MODEL1707114734 MODEL1707114735 MODEL1707114736 MODEL1707114737 MODEL1707114738 MODEL1707114739 MODEL1707114740 MODEL1707114741 MODEL1707114742 MODEL1707114743 MODEL1707114744 MODEL1707114745 MODEL1707114746 MODEL1707114747 MODEL1707114748 MODEL1707114749 MODEL1707114750 MODEL1707114751 MODEL1707114752 MODEL1707114753 MODEL1707114754 MODEL1707114755 MODEL1707114756 MODEL1707114757 MODEL1707114758 MODEL1707114759 MODEL1707114760 MODEL1707115133 MODEL1707115134 MODEL1707115135 MODEL1707115136 MODEL1707115137 MODEL1707115347 MODEL1707115348 MODEL1707115349 MODEL1707115350 MODEL1707115351 MODEL1707115352 MODEL1707115353 MODEL1707115354 MODEL1707115355 MODEL1707115356 MODEL1707115357 MODEL1707115358 MODEL1707115359 MODEL1707115360 MODEL1707115361 MODEL1707115362 MODEL1707115363 MODEL1707115364 MODEL1707115365 MODEL1707115366 MODEL1707115367 MODEL1707115368 MODEL1707115369 MODEL1707115370 MODEL1707115371 MODEL1707115372 MODEL1707115373 MODEL1707115374 MODEL1707115375 MODEL1707115376 MODEL1707115377 MODEL1707115378 MODEL1707115379 MODEL1707115380 MODEL1707115381 MODEL1707115382 MODEL1707115383 MODEL1707115384 MODEL1707115385 MODEL1707115386 MODEL1707115387 MODEL1707115388 MODEL1707115389 MODEL1707115475 MODEL1707115476 MODEL1707115477 MODEL1707115478 MODEL1707115479 MODEL1707115480 MODEL1707115481 MODEL1707115482 MODEL1707115483 MODEL1707115484 MODEL1707115485 MODEL1707115486 MODEL1707115487 MODEL1707115488 MODEL1707115489 MODEL1707115490 MODEL1707115491 MODEL1707115492 MODEL1707115493 MODEL1707115494 MODEL1707115495 MODEL1707115496 MODEL1707115497 MODEL1707115498 MODEL1707115499 MODEL1707115500 MODEL1707115501 MODEL1707115502 MODEL1707115503 MODEL1707115504 MODEL1707115505 MODEL1707115506 MODEL1707115507 MODEL1707115508 MODEL1707115509 MODEL1707115510 MODEL1707115511 MODEL1707115512 MODEL1707115513 MODEL1707115514 MODEL1707115515 MODEL1707115516 MODEL1707115517 MODEL1707115518 MODEL1707115519 MODEL1707115520 MODEL1707115521 MODEL1707115522 MODEL1707115523 MODEL1707115524 MODEL1707115525 MODEL1707115526 MODEL1707115527 MODEL1707115528 MODEL1707115529 MODEL1707115530 MODEL1707115531 MODEL1707115532 MODEL1707115533 MODEL1707115534 MODEL1707115535 MODEL1707115536 MODEL1707115537 MODEL1707115538 MODEL1707115559 MODEL1707115560 MODEL1707115561 MODEL1707115562 MODEL1707115724 MODEL1707115725 MODEL1707115726 MODEL1707115727 MODEL1707115728 MODEL1707115729 MODEL1707115730 MODEL1707115731 MODEL1707115732 MODEL1707115733 MODEL1707115734 MODEL1707115735 MODEL1707115736 MODEL1707115737 MODEL1707115738 MODEL1707115739 MODEL1707115740 MODEL1707115741 MODEL1707115742 MODEL1707115743 MODEL1707115744 MODEL1707115758 MODEL1707115759 MODEL1707115760 MODEL1707115761 MODEL1707115762 MODEL1707115763 MODEL1707115764 MODEL1707115765 MODEL1707115766 MODEL1707115800 MODEL1707115801 MODEL1707115802 MODEL1707115803 MODEL1707115804 MODEL1707115805 MODEL1707115806 MODEL1707115807 MODEL1707115808 MODEL1707115810 MODEL1707115811 MODEL1707115812 MODEL1707115813 MODEL1707115814 MODEL1707115815 MODEL1707115816 MODEL1707115817 MODEL1707115818 MODEL1707115819 MODEL1707115820 MODEL1707115821 MODEL1707115822 MODEL1707115823 MODEL1707115824 MODEL1707115825 MODEL1707115826 MODEL1707115827 MODEL1707115828 MODEL1707115829 MODEL1707115830 MODEL1707115831 MODEL1707115832 MODEL1707115833 MODEL1707115834 MODEL1707115835 MODEL1707115836 MODEL1707115837 MODEL1707115838 MODEL1707115839 MODEL1707115840 MODEL1707115841 MODEL1707115842 MODEL1707115843 MODEL1707115844 MODEL1707115845 MODEL1707115846 MODEL1707115847 MODEL1707115848 MODEL1707115849 MODEL1707115850 MODEL1707115851 MODEL1707115852 MODEL1707115986 MODEL1707115987 MODEL1707115988 MODEL1707115989 MODEL1707115990 MODEL1707115991 MODEL1707115992 MODEL1707115993 MODEL1707116191 MODEL1707116192 MODEL1707116193 MODEL1707116194 MODEL1707116195 MODEL1707116261 MODEL1707116285 MODEL1707116288 MODEL1707116350 MODEL1707116351 MODEL1707116352 MODEL1707116353 MODEL1707116354 MODEL1707116355 MODEL1707116356 MODEL1707116357 MODEL1707116358 MODEL1707116359 MODEL1707116360 MODEL1707116361 MODEL1707116362 MODEL1707116363 MODEL1707116364 MODEL1707116365 MODEL1707116366 MODEL1707116367 MODEL1707116368 MODEL1707116369 MODEL1707116370 MODEL1707116371 MODEL1707116372 MODEL1707116373 MODEL1707116374 MODEL1707116375 MODEL1707116376 MODEL1707116377 MODEL1707116378 MODEL1707116379 MODEL1707116390 MODEL1707116391 MODEL1707116392 MODEL1707116393 MODEL1707116394 MODEL1707116395 MODEL1707116396 MODEL1707116397 MODEL1707116398 MODEL1707116399 MODEL1707116400 MODEL1707116401 MODEL1707116402 MODEL1707116403 MODEL1707116404 MODEL1707116405 MODEL1707116406 MODEL1707116407 MODEL1707116408 MODEL1707116409 MODEL1707116410 MODEL1707116411 MODEL1707116524 MODEL1707116525 MODEL1707116526 MODEL1707116588 MODEL1707116589 MODEL1707116590 MODEL1707116591 MODEL1707116592 MODEL1707116593 MODEL1707116594 MODEL1707116595 MODEL1707116596 MODEL1707116597 MODEL1707116598 MODEL1707116599 MODEL1707116600 MODEL1707116601 MODEL1707116604 MODEL1707116605 MODEL1707116622 MODEL1707116639 MODEL1707116640 MODEL1707116641 MODEL1707116642 MODEL1707116643 MODEL1707116644 MODEL1707116645 MODEL1707116646 MODEL1707116647 MODEL1707116648 MODEL1707116649 MODEL1707116650 MODEL1707116651 MODEL1707116652 MODEL1707116653 MODEL1707116654 MODEL1707116655 MODEL1707116656 MODEL1707116657 MODEL1707116658 MODEL1707116659 MODEL1707116660 MODEL1707116661 MODEL1707116662 MODEL1707116663 MODEL1707116664 MODEL1707116665 MODEL1707116706 MODEL1707116707 MODEL1707116708 MODEL1707116709 MODEL1707116710 MODEL1707116711 MODEL1707116712 MODEL1707116713 MODEL1707116714 MODEL1707116715 MODEL1707116716 MODEL1707116717 MODEL1707116718 MODEL1707116719 MODEL1707116720 MODEL1707116721 MODEL1707116722 MODEL1707116723 MODEL1707116724 MODEL1707116725 MODEL1707116726 MODEL1707116727 MODEL1707116728 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome. Click here to expand
  • Mathias Uhlen, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma Lundberg, Sophia Hober, Peter Nilsson, Johanna Mattsson, Jochen M Schwenk, Hans Brunnström, Bengt Glimelius, Tobias Sjöblom, Per-Henrik Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoglu, Fredrik Ponten
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , pages: eaan2507 , PubMed ID: 28818916
  • Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu
Curator: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1707110430

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (3 statements)
Human Disease Ontology prostate adenocarcinoma
Mathematical Modelling Ontology Constraint-based model
PATO male

isDerivedFrom (2 statements)
Genomic Data Commons Data Portal 49197847-cc83-4ce1-8397-d09cea4c4928
BioModels Database MODEL1402200003

Curation status
Non-curated
Tags
Auto-Generated

Connected external resources