Model Identifier
MODEL1707110005
Short description

This is a whole genome metabolism model of a female patient diagnosed at the age of 80 years with Ovary Serous Cystadenocarcinoma affecting the patient's ovary.

This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-04-1331-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.

This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110005.

Other models with the same disease include MODEL1707110006 MODEL1707110007 MODEL1707110008 MODEL1707110009 MODEL1707110010 MODEL1707110011 MODEL1707110012 MODEL1707110013 MODEL1707110014 MODEL1707110015 MODEL1707110016 MODEL1707110017 MODEL1707110018 MODEL1707110019 MODEL1707110020 MODEL1707110021 MODEL1707110022 MODEL1707110023 MODEL1707110106 MODEL1707110107 MODEL1707110108 MODEL1707110109 MODEL1707110110 MODEL1707110111 MODEL1707110112 MODEL1707110113 MODEL1707110114 MODEL1707110115 MODEL1707110116 MODEL1707110117 MODEL1707110118 MODEL1707110119 MODEL1707110120 MODEL1707110121 MODEL1707110122 MODEL1707110123 MODEL1707110124 MODEL1707110125 MODEL1707110126 MODEL1707110136 MODEL1707110137 MODEL1707110138 MODEL1707110139 MODEL1707110140 MODEL1707110141 MODEL1707110142 MODEL1707110143 MODEL1707110144 MODEL1707110145 MODEL1707110146 MODEL1707110147 MODEL1707110148 MODEL1707110149 MODEL1707110150 MODEL1707110151 MODEL1707110152 MODEL1707110153 MODEL1707110154 MODEL1707110155 MODEL1707110156 MODEL1707110157 MODEL1707110158 MODEL1707110159 MODEL1707110160 MODEL1707110161 MODEL1707110162 MODEL1707110163 MODEL1707110164 MODEL1707110165 MODEL1707110166 MODEL1707110167 MODEL1707110168 MODEL1707110169 MODEL1707110170 MODEL1707110171 MODEL1707110172 MODEL1707110173 MODEL1707110174 MODEL1707110175 MODEL1707110176 MODEL1707110177 MODEL1707110178 MODEL1707110179 MODEL1707110180 MODEL1707110181 MODEL1707110182 MODEL1707110183 MODEL1707110184 MODEL1707110218 MODEL1707110219 MODEL1707110261 MODEL1707110262 MODEL1707110263 MODEL1707110264 MODEL1707110265 MODEL1707110266 MODEL1707110267 MODEL1707110268 MODEL1707110269 MODEL1707110270 MODEL1707110271 MODEL1707110272 MODEL1707110273 MODEL1707110274 MODEL1707110275 MODEL1707110276 MODEL1707110277 MODEL1707110278 MODEL1707110279 MODEL1707110280 MODEL1707110281 MODEL1707110282 MODEL1707110283 MODEL1707110284 MODEL1707110285 MODEL1707110286 MODEL1707110287 MODEL1707110288 MODEL1707110289 MODEL1707110290 MODEL1707110291 MODEL1707110292 MODEL1707110293 MODEL1707110294 MODEL1707110295 MODEL1707110296 MODEL1707110297 MODEL1707110298 MODEL1707110299 MODEL1707110300 MODEL1707110301 MODEL1707110302 MODEL1707110303 MODEL1707110304 MODEL1707110305 MODEL1707110306 MODEL1707110307 MODEL1707110308 MODEL1707110309 MODEL1707110310 MODEL1707110311 MODEL1707110312 MODEL1707110313 MODEL1707110314 MODEL1707110315 MODEL1707110316 MODEL1707110317 MODEL1707110318 MODEL1707110319 MODEL1707110320 MODEL1707110321 MODEL1707110322 MODEL1707110323 MODEL1707110324 MODEL1707110325 MODEL1707110326 MODEL1707110327 MODEL1707110328 MODEL1707110329 MODEL1707110330 MODEL1707110331 MODEL1707110332 MODEL1707110333 MODEL1707110334 MODEL1707110335 MODEL1707110336 MODEL1707110337 MODEL1707110338 MODEL1707110339 MODEL1707110340 MODEL1707110341 MODEL1707110342 MODEL1707110343 MODEL1707110344 MODEL1707110345 MODEL1707110346 MODEL1707110347 MODEL1707110348 MODEL1707110349 MODEL1707110350 MODEL1707110351 MODEL1707110352 MODEL1707110353 MODEL1707110354 MODEL1707110355 MODEL1707110356 MODEL1707110357 MODEL1707110358 MODEL1707110359 MODEL1707110360 MODEL1707110361 MODEL1707110362 MODEL1707110363 MODEL1707110364 MODEL1707110365 MODEL1707110366 MODEL1707110367 MODEL1707110368 MODEL1707110369 MODEL1707110370 MODEL1707110371 MODEL1707110403 MODEL1707110404 MODEL1707110405 MODEL1707110406 MODEL1707110407 MODEL1707110408 MODEL1707110409 MODEL1707110410 MODEL1707110411 MODEL1707110412 MODEL1707110413 MODEL1707110414 MODEL1707110415 MODEL1707110416 MODEL1707110417 MODEL1707110418 MODEL1707110419 MODEL1707110420 MODEL1707110421 MODEL1707110422 MODEL1707110423 MODEL1707110424 MODEL1707110425 MODEL1707110426 MODEL1707110427 MODEL1707110428 MODEL1707110429 MODEL1707110566 MODEL1707110567 MODEL1707110568 MODEL1707110569 MODEL1707110570 MODEL1707110571 MODEL1707110572 MODEL1707110573 MODEL1707110574 MODEL1707110575 MODEL1707110576 MODEL1707110577 MODEL1707110578 MODEL1707110625 MODEL1707110626 MODEL1707110627 MODEL1707110628 MODEL1707110629 MODEL1707110630 MODEL1707110631 MODEL1707110954 MODEL1707110955 MODEL1707110956 MODEL1707110957 MODEL1707110958 MODEL1707110959 MODEL1707110969 MODEL1707110970 MODEL1707110971 MODEL1707110972 MODEL1707110973 MODEL1707110974 MODEL1707111004 MODEL1707111027 MODEL1707111028 MODEL1707111029 MODEL1707111030 MODEL1707111031 MODEL1707111032 MODEL1707111033 MODEL1707111034 MODEL1707111035 MODEL1707111036 MODEL1707111037 MODEL1707111038 MODEL1707111039 MODEL1707111040 MODEL1707111041 MODEL1707111042 MODEL1707111043 MODEL1707111044 MODEL1707111045 MODEL1707111046 MODEL1707111047 MODEL1707111048 MODEL1707111049 MODEL1707111050 MODEL1707111051 MODEL1707111052 MODEL1707111053 MODEL1707111054 MODEL1707111055 MODEL1707111056 MODEL1707111057 MODEL1707116119 MODEL1707116389 MODEL1707116512 .

To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
Format
SBML (L2V3)
Related Publication
  • A pathology atlas of the human cancer transcriptome. Click here to expand
  • Mathias Uhlen, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma Lundberg, Sophia Hober, Peter Nilsson, Johanna Mattsson, Jochen M Schwenk, Hans Brunnström, Bengt Glimelius, Tobias Sjöblom, Per-Henrik Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoglu, Fredrik Ponten
  • Science (New York, N.Y.) , 8/ 2017 , Volume 357 , Issue 6352 , pages: eaan2507 , PubMed ID: 28818916
  • Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.
Contributors
Submitter of the first revision: Adil Mardinoglu
Submitter of this revision: Adil Mardinoglu
Curator: Adil Mardinoglu

Metadata information

is (1 statement)
BioModels Database MODEL1707110005

hasTaxon (1 statement)
Taxonomy Homo sapiens

hasProperty (3 statements)
Human Disease Ontology ovarian serous cystadenocarcinoma
Mathematical Modelling Ontology Constraint-based model
PATO female

isDerivedFrom (2 statements)
Genomic Data Commons Data Portal 6d10d4ee-6331-4bba-93bc-a7b64cc0b22a
BioModels Database MODEL1402200003

Curation status
Non-curated
Tags
Auto-Generated

Connected external resources