Grigolon2018 - Feedback Loop in ARF and IAA Response

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Grigolon2018 - Feedback Loop in ARF and IAA Response

This model is described in the article:

Grigolon S, Bravi B, Martin OC.
R Soc Open Sci 2018 Jan; 5(1): 172098

Abstract:

Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the signal) on the auxin response factor (ARF) transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signalling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative feedback allows the system to have a far larger sensitivity in its dynamical response to auxin and that this sensitivity does not prevent the system from being highly resilient. Given this insight, we build a new biomolecular signalling model for quantitatively describing such Aux/IAA and ARF responses.

This model is hosted on BioModels Database and identified by: MODEL1706070000.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V3)
Related Publication
  • Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience.
  • Grigolon S, Bravi B, Martin OC
  • Royal Society open science , 1/ 2018 , Volume 5 , Issue 1 , pages: 172098
  • LPTMS, Université Paris-Sud XI-Université Paris-Saclay, 15, Rue Georges Clémenceau, 91405 Orsay, France.
  • Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the signal) on the auxin response factor (ARF) transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signalling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative feedback allows the system to have a far larger sensitivity in its dynamical response to auxin and that this sensitivity does not prevent the system from being highly resilient. Given this insight, we build a new biomolecular signalling model for quantitatively describing such Aux/IAA and ARF responses.
Contributors
Barbara Bravi

Metadata information

hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Non-curated
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  • Model originally submitted by : Barbara Bravi
  • Submitted: Jun 7, 2017 9:45:43 AM
  • Last Modified: Oct 12, 2018 5:24:57 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Oct 12, 2018 5:24:57 PM
    • Submitted by: Barbara Bravi
    • With comment: Current version of MODEL1706070000
  • Version: 1 public model Download this version
    • Submitted on: Jun 7, 2017 9:45:43 AM
    • Submitted by: Barbara Bravi
    • With comment: Original import of MODEL1706070000