Aubert2005 - Interaction between astrocytes and neurons on energy metabolism

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Short description
Aubert2005 - Interaction between astrocytes and neurons on energy metabolism
Enocded non-curated model. Issues:

- Confusing equations A.41 and A.42
- Missing values for parameters Vv,0 and dHb,0

This model is described in the article:

Aubert A, Costalat R.
J. Cereb. Blood Flow Metab. 2005 Nov; 25(11): 1476-1490

Abstract:

Understanding cerebral energy metabolism in neurons and astrocytes is necessary for the interpretation of functional brain imaging data. It has been suggested that astrocytes can provide lactate as an energy fuel to neurons, a process referred to as astrocyte-neuron lactate shuttle (ANLS). Some authors challenged this hypothesis, defending the classical view that glucose is the major energy substrate of neurons, at rest as well as in response to a stimulation. To test the ANLS hypothesis from a theoretical point of view, we developed a mathematical model of compartmentalized energy metabolism between neurons and astrocytes, adopting hypotheses highly unfavorable to ANLS. Simulation results can be divided between two groups, depending on the relative neuron versus astrocyte stimulation. If this ratio is low, ANLS is observed during all the stimulus and poststimulus periods (continuous ANLS), but a high ratio induces ANLS only at the beginning of the stimulus and during the poststimulus period (triphasic behavior). Finally, our results show that current experimental data on lactate kinetics are compatible with the ANLS hypothesis, and that it is essential to assess the neuronal and astrocytic NADH/NAD+ ratio changes to test the ANLS hypothesis.

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Format
SBML (L2V4)
Related Publication
  • Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism.
  • Aubert A, Costalat R
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism , 11/ 2005 , Volume 25 , pages: 1476-1490
  • INSERM U494, CHU Pitié-Salpêtrière, Paris, France.
  • Understanding cerebral energy metabolism in neurons and astrocytes is necessary for the interpretation of functional brain imaging data. It has been suggested that astrocytes can provide lactate as an energy fuel to neurons, a process referred to as astrocyte-neuron lactate shuttle (ANLS). Some authors challenged this hypothesis, defending the classical view that glucose is the major energy substrate of neurons, at rest as well as in response to a stimulation. To test the ANLS hypothesis from a theoretical point of view, we developed a mathematical model of compartmentalized energy metabolism between neurons and astrocytes, adopting hypotheses highly unfavorable to ANLS. Simulation results can be divided between two groups, depending on the relative neuron versus astrocyte stimulation. If this ratio is low, ANLS is observed during all the stimulus and poststimulus periods (continuous ANLS), but a high ratio induces ANLS only at the beginning of the stimulus and during the poststimulus period (triphasic behavior). Finally, our results show that current experimental data on lactate kinetics are compatible with the ANLS hypothesis, and that it is essential to assess the neuronal and astrocytic NADH/NAD+ ratio changes to test the ANLS hypothesis.
Contributors
Audald Lloret i Villas

Metadata information

is
BioModels Database MODEL1411210000
isDescribedBy
PubMed 15931164
hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology brain
Curation status
Non-curated
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  • Model originally submitted by : Audald Lloret i Villas
  • Submitted: Nov 21, 2014 4:39:32 PM
  • Last Modified: Nov 21, 2014 4:45:24 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Nov 21, 2014 4:45:24 PM
    • Submitted by: Audald Lloret i Villas
    • With comment: Current version of Aubert2005 - Interaction between astrocytes and neurons on energy metabolism
  • Version: 1 public model Download this version
    • Submitted on: Nov 21, 2014 4:39:32 PM
    • Submitted by: Audald Lloret i Villas
    • With comment: Original import of Aubert2005 - Interaction between astrocytes and neurons on energy metabolism