Geier2011 - Integrin activation

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Model Identifier
MODEL1208280001
Short description
Geier2011 - Integrin activation

Rule based model that integrates the available data to test the biololical hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation.

This model is described in the article:

Geier F, Fengos G, Iber D.
PLoS One. 2011;6(11):e24808.

Abstract:

Integrin signaling regulates cell migration and plays a pivotal role in developmental processes and cancer metastasis. Integrin signaling has been studied extensively and much data is available on pathway components and interactions. Yet the data is fragmented and an integrated model is missing. We use a rule-based modeling approach to integrate available data and test biological hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. The detailed biochemical characterization of integrin signaling provides us with measured values for most of the kinetics parameters. However, measurements are not fully accurate and the cellular concentrations of signaling proteins are largely unknown and expected to vary substantially across different cellular conditions. By sampling model behaviors over the physiologically realistic parameter range we find that the model exhibits only two different qualitative behaviors and these depend mainly on the relative protein concentrations, which offers a powerful point of control to the cell. Our study highlights the necessity to characterize model behavior not for a single parameter optimum, but to identify parameter sets that characterize different signaling modes.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Format
SBML (L2V1)
Related Publication
  • A computational analysis of the dynamic roles of talin, Dok1, and PIPKI for integrin activation.
  • Geier F, Fengos G, Iber D
  • PloS one , 0/ 2011 , Volume 6 , pages: e24808 , PubMed ID: 22110576
  • Department of Biosystems Science and Engineering (D-BSSE), ETH Z├╝rich, Basel, Switzerland.
  • Integrin signaling regulates cell migration and plays a pivotal role in developmental processes and cancer metastasis. Integrin signaling has been studied extensively and much data is available on pathway components and interactions. Yet the data is fragmented and an integrated model is missing. We use a rule-based modeling approach to integrate available data and test biological hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. The detailed biochemical characterization of integrin signaling provides us with measured values for most of the kinetics parameters. However, measurements are not fully accurate and the cellular concentrations of signaling proteins are largely unknown and expected to vary substantially across different cellular conditions. By sampling model behaviors over the physiologically realistic parameter range we find that the model exhibits only two different qualitative behaviors and these depend mainly on the relative protein concentrations, which offers a powerful point of control to the cell. Our study highlights the necessity to characterize model behavior not for a single parameter optimum, but to identify parameter sets that characterize different signaling modes.
Contributors
Georgios Fengos

Metadata information

is
BioModels Database MODEL1208280001
isDescribedBy
PubMed 22110576
hasTaxon
Taxonomy Metazoa
isVersionOf
Gene Ontology integrin activation
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model

Curation status
Non-curated


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Model files

MODEL1208280001_url.xml SBML L2V1 representation of Geier2011 - Integrin activation 286.67 KB Preview | Download

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MODEL1208280001.png Auto-generated Reaction graph (PNG) 5.07 KB Preview | Download
MODEL1208280001.pdf Auto-generated PDF file 1.58 MB Preview | Download
MODEL1208280001-biopax3.owl Auto-generated BioPAX (Level 3) 794.53 KB Preview | Download
MODEL1208280001-biopax2.owl Auto-generated BioPAX (Level 2) 432.28 KB Preview | Download
MODEL1208280001.m Auto-generated Octave file 72.78 KB Preview | Download
MODEL1208280001.svg Auto-generated Reaction graph (SVG) 557.00 bytes Preview | Download
MODEL1208280001.sci Auto-generated Scilab file 44.64 KB Preview | Download
MODEL1208280001_urn.xml Auto-generated SBML file with URNs 325.13 KB Preview | Download
MODEL1208280001.vcml Auto-generated VCML file 506.42 KB Preview | Download
MODEL1208280001.xpp Auto-generated XPP file 55.19 KB Preview | Download

  • Model originally submitted by : Georgios Fengos
  • Submitted: 28-Aug-2012 18:02:42
  • Last Modified: 10-Apr-2014 19:59:43
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 10-Apr-2014 19:59:43
    • Submitted by: Georgios Fengos
    • With comment: Current version of Geier2011 - Integrin activation
  • Version: 1 public model Download this version
    • Submitted on: 28-Aug-2012 18:02:42
    • Submitted by: Georgios Fengos
    • With comment: Original import of PlosOne_Integrins_model
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