Kubota2012_InsulinAction_AKTpathway
This model is from the article:
Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway.
Kubota H, Noguchi R, Toyoshima Y, Ozaki Y, Uda S, Watanabe K, Ogawa W, Kuroda S. Mol Cell.
2012 Jun 29;46(6):820-32. 22633957
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Abstract:
One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin.
Note: Created by The MathWorks, Inc. SimBiology tool, Version 3.3
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Temporal coding of insulin action through multiplexing of the AKT pathway.
- Kubota H, Noguchi R, Toyoshima Y, Ozaki Y, Uda S, Watanabe K, Ogawa W, Kuroda S
- Molecular cell , 6/ 2012 , Volume 46 , pages: 820-832 , PubMed ID: 22633957
- Department of Biophysics, Graduate School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. kubota@bi.s.u-tokyo.ac.jp
- One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin.
Submitter of this revision: Hiroyuki Kubota
Modellers: Hiroyuki Kubota
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- Model originally submitted by : Hiroyuki Kubota
- Submitted: Apr 6, 2012 8:45:26 AM
- Last Modified: Aug 3, 2012 12:57:55 PM
Revisions
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Version: 2
- Submitted on: Aug 3, 2012 12:57:55 PM
- Submitted by: Hiroyuki Kubota
- With comment: Current version of Kubota2012_InsulinAction_AKTpathway
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Version: 1
- Submitted on: Apr 6, 2012 8:45:26 AM
- Submitted by: Hiroyuki Kubota
- With comment: Original import of Kubota2012_AKT_insulin3
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