Kubota2012_InsulinAction_AKTpathway

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Model Identifier
MODEL1204060000
Short description

This model is from the article:
Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway.
Kubota H, Noguchi R, Toyoshima Y, Ozaki Y, Uda S, Watanabe K, Ogawa W, Kuroda S. Mol Cell. 2012 Jun 29;46(6):820-32. 22633957 ,
Abstract:
One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin.


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SBML (L2V4)
Related Publication
  • Temporal coding of insulin action through multiplexing of the AKT pathway.
  • Kubota H, Noguchi R, Toyoshima Y, Ozaki Y, Uda S, Watanabe K, Ogawa W, Kuroda S
  • Molecular cell , 6/ 2012 , Volume 46 , pages: 820-832 , PubMed ID: 22633957
  • Department of Biophysics, Graduate School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. kubota@bi.s.u-tokyo.ac.jp
  • One of the unique characteristics of cellular signaling pathways is that a common signaling pathway can selectively regulate multiple cellular functions of a hormone; however, this selective downstream control through a common signaling pathway is poorly understood. Here we show that the insulin-dependent AKT pathway uses temporal patterns multiplexing for selective regulation of downstream molecules. Pulse and sustained insulin stimulations were simultaneously encoded into transient and sustained AKT phosphorylation, respectively. The downstream molecules, including ribosomal protein S6 kinase (S6K), glucose-6-phosphatase (G6Pase), and glycogen synthase kinase-3β (GSK3β) selectively decoded transient, sustained, and both transient and sustained AKT phosphorylation, respectively. Selective downstream decoding is mediated by the molecules' network structures and kinetics. Our results demonstrate that the AKT pathway can multiplex distinct patterns of blood insulin, such as pulse-like additional and sustained-like basal secretions, and the downstream molecules selectively decode secretion patterns of insulin.
Contributors
Submitter of the first revision: Hiroyuki Kubota
Submitter of this revision: Hiroyuki Kubota
Modellers: Hiroyuki Kubota

Metadata information

is (1 statement)
BioModels Database MODEL1204060000

isDescribedBy (1 statement)
PubMed 22633957

hasTaxon (1 statement)
Taxonomy Rattus

isVersionOf (1 statement)
hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model

occursIn (1 statement)
Brenda Tissue Ontology liver


Curation status
Non-curated


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  • Model originally submitted by : Hiroyuki Kubota
  • Submitted: Apr 6, 2012 8:45:26 AM
  • Last Modified: Aug 3, 2012 12:57:55 PM
Revisions
  • Version: 2 public model Download this version
    • Submitted on: Aug 3, 2012 12:57:55 PM
    • Submitted by: Hiroyuki Kubota
    • With comment: Current version of Kubota2012_InsulinAction_AKTpathway
  • Version: 1 public model Download this version
    • Submitted on: Apr 6, 2012 8:45:26 AM
    • Submitted by: Hiroyuki Kubota
    • With comment: Original import of Kubota2012_AKT_insulin3

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