Nazaret2008_Dynnik1980_CarbohydrateEnergyMetabolism

This model is from the article:
An old paper revisited: ‘‘A mathematical model of carbohydrate energy
metabolism. Interaction between glycolysis, the Krebs cycle and the
H-transporting shuttles at varying ATPases load’’ by V.V. Dynnik,
R. Heinrich and E.E. Sel’kov
Nazaret C, Mazat JP. J Theor Biol
2008 Jun;252(3):520-9. 18304584
,
Abstract:
We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel’kov (1980a, b) describing: ‘‘A mathematical model of
carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases
load’’. We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the
structure of the metabolic network in terms of elementary flux modes.
We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can
help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the
H-transporting shuttles.
Note: "dynnik_v1.xml":
- created directly from "heinrich.sci" model file provided by Christine Nazaret
- IDs changed to as per the paper
- initial conditions set to steady state
- results of Fig. 3 may be reproduced by running a a parameter scan over b15 in COPASI
"dynnik_v2.xml":
- rescaled species such as s2_e1 = s2 * e1 are introduced whose evolution may be described through reaction participation, rather than via ODEs
- original variables are retained as global parameters
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An old paper revisited: "a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load" by V.V. Dynnik, R. Heinrich and E.E. Sel'kov.
- Nazaret C, Mazat JP
- Journal of theoretical biology , 6/ 2008 , Volume 252 , pages: 520-529 , PubMed ID: 18304584
- IMB, Université de Bordeaux 2, 146 Rue Léo-Saignat, F 33076 Bordeaux-cedex, France. nazaret@sm.u-bordeaux2.fr
- We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a,b) describing: "A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load". We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes. We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.
Submitter of this revision: Kieran Smallbone
Modellers: Kieran Smallbone
Metadata information
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hasTaxon (1 statement)
isVersionOf (1 statement)
hasProperty (1 statement)
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MODEL1202170000_url.xml | SBML L2V4 representation of Nazaret2008_Dynnik1980_CarbohydrateEnergyMetabolism | 51.32 KB | Preview | Download |
Additional files |
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MODEL1202170000-biopax2.owl | Auto-generated BioPAX (Level 2) | 24.66 KB | Preview | Download |
MODEL1202170000-biopax3.owl | Auto-generated BioPAX (Level 3) | 515.00 Bytes | Preview | Download |
MODEL1202170000.m | Auto-generated Octave file | 9.97 KB | Preview | Download |
MODEL1202170000.pdf | Auto-generated PDF file | 2.80 KB | Preview | Download |
MODEL1202170000.png | Auto-generated Reaction graph (PNG) | 226.54 KB | Preview | Download |
MODEL1202170000.sci | Auto-generated Scilab file | 154.00 Bytes | Preview | Download |
MODEL1202170000.svg | Auto-generated Reaction graph (SVG) | 42.26 KB | Preview | Download |
MODEL1202170000.vcml | Auto-generated VCML file | 605.00 Bytes | Preview | Download |
MODEL1202170000.xpp | Auto-generated XPP file | 7.23 KB | Preview | Download |
MODEL1202170000_urn.xml | Auto-generated SBML file with URNs | 56.50 KB | Preview | Download |
- Model originally submitted by : Kieran Smallbone
- Submitted: Feb 17, 2012 11:11:05 AM
- Last Modified: May 11, 2012 2:05:24 PM
Revisions
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Version: 2
- Submitted on: May 11, 2012 2:05:24 PM
- Submitted by: Kieran Smallbone
- With comment: Current version of Nazaret2008_Dynnik1980_CarbohydrateEnergyMetabolism
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Version: 1
- Submitted on: Feb 17, 2012 11:11:05 AM
- Submitted by: Kieran Smallbone
- With comment: Original import of dynnik
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