Ciliberto2003_Swe1Network

  public model
Short description

This a model from the article:
Mathematical model of the morphogenesis checkpoint in budding yeast.
Ciliberto A, Novak B, Tyson JJ. J Cell Biol 2003 Dec 22;163(6):1243-54 14691135 ,
Abstract:
The morphogenesis checkpoint in budding yeast delays progression through the cell cycle in response to stimuli that prevent bud formation. Central to the checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts cell cycle progression in G2. We propose a molecular network for Swe1 control, based on published observations of budding yeast and analogous control signals in fission yeast. The proposed Swe1 network is merged with a model of cyclin-dependent kinase regulation, converted into a set of differential equations and studied by numerical simulation. The simulations accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Ciliberto A, Novak B, Tyson JJ. (2003) - version03
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not..

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • Mathematical model of the morphogenesis checkpoint in budding yeast.
  • Ciliberto A, Novak B, Tyson JJ
  • The Journal of cell biology , 12/ 2003 , Volume 163 , pages: 1243-1254
  • Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
  • The morphogenesis checkpoint in budding yeast delays progression through the cell cycle in response to stimuli that prevent bud formation. Central to the checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts cell cycle progression in G2. We propose a molecular network for Swe1 control, based on published observations of budding yeast and analogous control signals in fission yeast. The proposed Swe1 network is merged with a model of cyclin-dependent kinase regulation, converted into a set of differential equations and studied by numerical simulation. The simulations accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0913285268
isDescribedBy
PubMed 14691135
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
isVersionOf

Curation status
Non-curated


Original model(s)
http://www.cellml.org/models/ciliberto_novak_tyson_2003_version03

Tags
Name Description Size Actions

Model files

MODEL0913285268_url.xml SBML L2V3 representation of Ciliberto2003_Swe1Network 40.71 KB Preview | Download

Additional files

MODEL0913285268.xpp Auto-generated XPP file 10.63 KB Preview | Download
MODEL0913285268-biopax2.owl Auto-generated BioPAX (Level 2) 1.05 KB Preview | Download
MODEL0913285268-biopax3.owl Auto-generated BioPAX (Level 3) 1.99 KB Preview | Download
MODEL0913285268_urn.xml Auto-generated SBML file with URNs 45.63 KB Preview | Download
MODEL0913285268.svg Auto-generated Reaction graph (SVG) 851.00 bytes Preview | Download
MODEL0913285268.pdf Auto-generated PDF file 164.81 KB Preview | Download
MODEL0913285268.png Auto-generated Reaction graph (PNG) 5.04 KB Preview | Download
MODEL0913285268.vcml Auto-generated VCML file 900.00 bytes Preview | Download
MODEL0913285268.m Auto-generated Octave file 14.78 KB Preview | Download
MODEL0913285268.sci Auto-generated Scilab file 181.00 bytes Preview | Download

  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 28-Apr-2009 13:01:34
  • Last Modified: 12-Jan-2011 18:37:27
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 12-Jan-2011 18:37:27
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Ciliberto2003_Swe1Network
  • Version: 1 public model Download this version
    • Submitted on: 28-Apr-2009 13:01:34
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Ciliberto2003_Swe1Network