Hinch2004_VentricularMyocytes

  public model
Short description

This a model from the article:
A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. Biophys J 2004 Dec;87(6):3723-36 15465866 ,
Abstract:
Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. (2004) - version02
The original CellML model was created by:
Terkildsen, Jonna,
j.terkildsen@auckland.ac.nz
University of Auckland
Auckland Bioengineering Institute

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V3)
Related Publication
  • A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.
  • Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL
  • Biophysical Journal , 12/ 2004 , Volume 87 , pages: 3723-3736
  • Mathematical Institute, University of Oxford, Oxford, United Kingdom. hinch@maths.ox.ac.uk
  • Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.
Contributors
Vijayalakshmi Chelliah

Metadata information

is
BioModels Database MODEL0848342500
isDescribedBy
PubMed 15465866
hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
occursIn
Brenda Tissue Ontology cardiac muscle fiber
Curation status
Non-curated
Original model(s)
http://www.cellml.org/models/hinch_greenstein_tanskanen_xu_winslow_2004_version02
Name Description Size Actions

Model file

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Additional files

MODEL0848342500-biopax3.owl Auto-generated BioPAX (Level 3) 2.00 KB Preview | Download
MODEL0848342500.pdf Auto-generated PDF file 222.68 KB Preview | Download
MODEL0848342500_urn.xml Auto-generated SBML file with URNs 85.11 KB Preview | Download
MODEL0848342500.m Auto-generated Octave file 17.54 KB Preview | Download
MODEL0848342500.vcml Auto-generated VCML file 900.00 bytes Preview | Download
MODEL0848342500.svg Auto-generated Reaction graph (SVG) 851.00 bytes Preview | Download
MODEL0848342500.xpp Auto-generated XPP file 15.86 KB Preview | Download
MODEL0848342500.png Auto-generated Reaction graph (PNG) 5.04 KB Preview | Download
MODEL0848342500-biopax2.owl Auto-generated BioPAX (Level 2) 1.05 KB Preview | Download
MODEL0848342500.sci Auto-generated Scilab file 275.00 bytes Preview | Download

  • Model originally submitted by : Vijayalakshmi Chelliah
  • Submitted: 28-Apr-2009 13:26:10
  • Last Modified: 28-Apr-2009 13:26:10
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 28-Apr-2009 13:26:10
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Current version of Hinch2004_VentricularMyocytes
  • Version: 1 public model Download this version
    • Submitted on: 28-Apr-2009 13:26:10
    • Submitted by: Vijayalakshmi Chelliah
    • With comment: Original import of Hinch2004_VentricularMyocytes