Palmer2008 - Negative Feedback in IL-7 mediated Jak-Stat signaling

  public model
Model Identifier
BIOMD0000000968
Short description
Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.
Format
SBML (L3V1)
Related Publication
  • Interleukin-7 receptor signaling network: an integrated systems perspective.
  • Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J
  • Cellular & molecular immunology , 4/ 2008 , Volume 5 , Issue 2 , pages: 79-89 , PubMed ID: 18445337
  • Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.
Contributors
Gladys Langi, Kausthubh Ramachandran

Metadata information

hasTaxon
Taxonomy Homo sapiens
hasProperty
Mathematical Modelling Ontology Ordinary differential equation model
GO:0050670
isDescribedBy
occursIn

Curation status
Curated


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Model files

Palmer2008.xml SBML L3V1 file of Negative Feedback in IL-7 mediated Jak-Stat signaling 54.81 KB Preview | Download

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Palmer2008.omex COMBINE archive of Negative Feedback in IL-7 mediated Jak-Stat signaling 13.34 KB Preview | Download
Palmer2008.sedml SED-ML file of Negative Feedback in IL-7 mediated Jak-Stat signaling 3.42 KB Preview | Download
Palmer2008.cps COPASI 4.29 (Build 228) file of Negative Feedback in IL-7 mediated Jak-Stat signaling 77.95 KB Preview | Download

  • Model originally submitted by : Gladys Langi
  • Submitted: 16-Oct-2020 13:40:56
  • Last Modified: 16-Oct-2020 13:40:56
Revisions
  • Version: 5 public model Download this version
    • Submitted on: 16-Oct-2020 13:40:56
    • Submitted by: Kausthubh Ramachandran
    • With comment: Automatically added model identifier BIOMD0000000968
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Curator's comment:
(added: 16 Oct 2020, 13:39:46, updated: 16 Oct 2020, 13:39:46)
Fig 5b from the manuscript is reproduced here. The initial value for IL-7R.pJak1 specified in the paper was used for specifying the initial value of IL-7R.Jak1. The specification Y = 100000 cell/L from the manuscript was not used.