Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction

  public model
Model Identifier
BIOMD0000000812
Short description 
This is a mathematical model that describes the interactions between cytotoxic T cells and tumor cells as influenced by B7-H1 (PD-L1) activity, with a focus on how B7-H1 affects cancer cells apoptosis.
Format
SBML (L2V4)
Related Publication
  • B7-h1 and a mathematical model for cytotoxic T cell and tumor cell interaction.
  • Galante A, Tamada K, Levy D
  • Bulletin of mathematical biology , 1/ 2012 , Volume 74 , Issue 1 , pages: 91-102 , PubMed ID: 21656310
  • Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland, College Park, MD, 20742, USA. agalante@cscamm.umd.edu
  • The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7-H1-negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathematical model for studying the interaction between cytotoxic T cells and tumor cells as affected by B7-H1. By integrating experimental data into the model, we isolate the parameters that control the dynamics and obtain insights on the mechanisms that control apoptosis.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Rahuman Sheriff
Modellers: Rahuman Sheriff, Johannes Meyer

Metadata information

is (2 statements)
BioModels Database MODEL1909160001
BioModels Database BIOMD0000000812

isDescribedBy (1 statement)
PubMed 21656310

isDerivedFrom (1 statement)
PubMed 15705911

hasProperty (3 statements)
Mathematical Modelling Ontology Ordinary differential equation model
Taxonomy Homo sapiens
Gene Ontology programmed cell death

Curation status
Curated
Tags
Immuno-oncology

Connected external resources

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Name Description Size Actions

Model files
Galante2012.xml SBML L2V4 Representation of Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction 45.94 KB Preview | Download

Additional files
Galante2012.cps COPASI file of Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction 75.48 KB Preview | Download
Galante2012.sedml SED-ML file of Galante2012 - B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction 3.43 KB Preview | Download

  • Model originally submitted by : Johannes Meyer
  • Submitted: Sep 16, 2019 10:03:46 AM
  • Last Modified: Oct 5, 2021 1:31:51 PM
Revisions
  • Version: 6 public model Download this version
    • Submitted on: Oct 5, 2021 1:31:51 PM
    • Submitted by: Rahuman Sheriff
    • With comment: Automatically added model identifier BIOMD0000000812
  • Version: 2 public model Download this version
    • Submitted on: Sep 16, 2019 10:03:46 AM
    • Submitted by: Johannes Meyer
    • With comment: Automatically added model identifier BIOMD0000000812

(*) You might be seeing discontinuous revisions as only public revisions are displayed here. Any private revisions unpublished model revision of this model will only be shown to the submitter and their collaborators.

Legends
: Variable used inside SBML models


Species
Species Initial Concentration/Amount
X Complex

cytotoxic T cell ; neoplastic cell ; Complex 		0.0 item
C Cancer Uncomplexed

neoplastic cell 		1.0 item
T ast

neoplastic cell 		1.0 item
P Perforin

Perforin 		0.315 item
E CTL

cytotoxic T cell 		1.0 item
Reactions
Reactions Rate Parameters
X_Complex => C_Cancer_Uncomplexed compartment*k_2*X_Complex k_2 = 1.0E-4
=> C_Cancer_Uncomplexed compartment*k*C_Cancer_Uncomplexed k = 0.035
T_ast => compartment*k_5*T_ast^2 k_5 = 0.003
=> P_Perforin; E_CTL, C_Cancer_Uncomplexed compartment*k_p*E_CTL/((k_m_1+E_CTL)*k_m_2*C_Cancer_Uncomplexed) k_p = 0.097; k_m_2 = 80.0; k_m_1 = 2.2
=> T_ast compartment*k*T_ast k = 0.035
C_Cancer_Uncomplexed => compartment*k_5*C_Cancer_Uncomplexed^2 k_5 = 0.003
X_Complex => compartment*k_3*X_Complex k_3 = 1.0E-4
C_Cancer_Uncomplexed => X_Complex; E_CTL compartment*k_1*C_Cancer_Uncomplexed*E_CTL k_1 = 1.0E-4
E_CTL = ModelValue_11-X_Complex [] ModelValue_11 = 1.0
Curator's comment:
(added: 16 Sep 2019, 10:03:23, updated: 16 Sep 2019, 10:03:23)
Reproduced plot of Figure 3 (Right Panel) in the original publication. Initial conditions are as indicated in the paper and the figure caption. Model simulated and plot produced using COPASI 4.24 (Build 197).