Model Identifier
BIOMD0000000811
Short description 
This is a mathematical model of pancreatic cancer which includes descriptions of regulatory T cell activity and inhibition therapy. Descriptions of cytokine induced killer immunotherapy are also included.
Format
SBML (L2V4)
Related Publication
  • A mathematical model of pancreatic cancer with two kinds of treatments Click here to expand
  • He, D.-H., Xu, J.-X.
  • Journal of Biological Systems , 3/ 2017 , Volume 25 , Issue 1 , pages: 83-104 , DOI: 10.1142/S021833901750005X
  • Department of Mathematics, Zhejiang International Studies University, HangZhou, 310012, China
  • In this paper, we investigate a mathematical model of pancreatic cancer, which extends the existing pancreatic cancer models with regulatory T cells (Tregs) and Treg inhibitory therapy. The model consists of tumor-immune interaction and immune suppression from Tregs. In the absence of treatments, we first characterize the system dynamics by locating equilibrium points and determining stability properties. Next, cytokine induced killer (CIK) immunotherapy is incorporated. Numerical simulations of prognostic results illustrate that the median overall survival associated with treatment can be prolonged approximately from 7 to 13 months, which is consistent with the clinical data. Furthermore, we consider cyclophosphamide (CTX) therapy as well as the combined therapy with CIK and CTX. Intensive simulation results suggest that both CTX therapy and the combined CIK/CTX therapy can reduce the number of Tregs and increase the overall survival (OS), but Tregs and tumor cells will gradually rise to equilibrium state as long as therapies are ceased.
Contributors
Submitter of the first revision: Johannes Meyer
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: Johannes Meyer, Rahuman S Malik-Sheriff

Metadata information

is (2 statements)
BioModels Database BIOMD0000000811
BioModels Database MODEL1909120001

isDerivedFrom (1 statement)
PubMed 8186756

hasProperty (4 statements)
isDescribedBy (1 statement)
Curation status
Curated
Modelling approach(es)
ordinary differential equation model
Tags
Immuno-oncology

Connected external resources

Visualisation of this model on Menelmacar platform