Wierschem2004 - Electrical bursting activity in Pancreatic Islets
This a model from the article:
Complex bursting in pancreatic islets: a potential glycolytic mechanism.
Wierschem K, Bertram R. J Theor Biol
2004 Jun 21;228(4):513-21 15178199
,
Abstract:
The electrical activity of insulin-secreting pancreatic islets of Langerhans is
characterized by bursts of action potentials. Most often this bursting is
periodic, but in some cases it is modulated by an underlying slower rhythm. We
suggest that the modulatory rhythm for this complex bursting pattern is due to
oscillations in glycolysis, while the bursting itself is generated by some other
slow process. To demonstrate this hypothesis, we couple a minimal model of
glycolytic oscillations to a minimal model for activity-dependent bursting in
islets. We show that the combined model can reproduce several complex bursting
patterns from mouse islets published in the literature, and we illustrate how
these complex oscillations are produced through the use of a fast/slow analysis.
This model was taken from the CellML repository
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The original model was:
Wierschem K, Bertram R. () - version=1.0
The original CellML model was created by:
Ethan Choi
mcho099@aucklanduni.ac.nz
The University of Auckland
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Complex bursting in pancreatic islets: a potential glycolytic mechanism.
- Wierschem K, Bertram R
- Journal of theoretical biology , 6/ 2004 , Volume 228 , Issue 4 , pages: 513-521 , PubMed ID: 15178199
- Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA.
- The electrical activity of insulin-secreting pancreatic islets of Langerhans is characterized by bursts of action potentials. Most often this bursting is periodic, but in some cases it is modulated by an underlying slower rhythm. We suggest that the modulatory rhythm for this complex bursting pattern is due to oscillations in glycolysis, while the bursting itself is generated by some other slow process. To demonstrate this hypothesis, we couple a minimal model of glycolytic oscillations to a minimal model for activity-dependent bursting in islets. We show that the combined model can reproduce several complex bursting patterns from mouse islets published in the literature, and we illustrate how these complex oscillations are produced through the use of a fast/slow analysis.
Submitter of this revision: administrator
Modellers: administrator, Camille Laibe
Metadata information
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hasTaxon (1 statement)
isVersionOf (1 statement)
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| BIOMD0000000682-biopax2.owl | Auto-generated BioPAX (Level 2) | 4.35 KB | Preview | Download |
| BIOMD0000000682-biopax3.owl | Auto-generated BioPAX (Level 3) | 4.74 KB | Preview | Download |
| BIOMD0000000682.m | Auto-generated Octave file | 5.92 KB | Preview | Download |
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| MODEL1006230006.cps | Curated and annotated COPASI file. | 64.73 KB | Preview | Download |
| MODEL1006230006.sedml | SED-ML file for figure 9 of the reference publication. | 2.34 KB | Preview | Download |
- Model originally submitted by : Camille Laibe
- Submitted: Jun 23, 2010 10:11:51 AM
- Last Modified: Mar 14, 2018 9:28:43 AM
Revisions
-
Version: 3
- Submitted on: Mar 14, 2018 9:28:43 AM
- Submitted by: administrator
- With comment: Model name updated using online editor.
-
Version: 2
- Submitted on: Jun 25, 2010 1:07:02 PM
- Submitted by: Camille Laibe
- With comment: Current version of Wierschem2004_PancreaticIslets_ActionPotentials
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Version: 1
- Submitted on: Jun 23, 2010 10:11:51 AM
- Submitted by: Camille Laibe
- With comment: Original import of Wierschem2004_PancreaticIslets_ActionPotentials
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(added: 08 Mar 2018, 09:00:57, updated: 08 Mar 2018, 09:00:57)