Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant

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Short description
Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant

This model is described in the article:

Araujo AR, Gelens L, Sheriff RS, Santos SD.
Mol. Cell 2016 Oct; 64(2): 362-375

Abstract:

Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is temporally insulated from variability in earlier cell-cycle phases. By combining live cell imaging and computational modeling, we showed that positive feedback is the molecular mechanism underlying the temporal insulation of mitosis. Perturbing positive feedback gave rise to a sluggish, variable entry and progression through mitosis and uncoupled duration of mitosis from variability in cell cycle length. We show that positive feedback is important to keep mitosis short, constant, and temporally insulated and anticipate it might be a commonly used regulatory strategy to create modularity in other biological systems.

This model is hosted on BioModels Database and identified by: BIOMD0000000657.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

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Format
SBML (L2V4)
Contributors
Rahuman Sheriff

Metadata information

is
BioModels Database MODEL1710040001
BioModels Database BIOMD0000000657
isDescribedBy
PubMed 27768873
hasTaxon
Taxonomy Homo sapiens
hasPart
Pathway Ontology M phase pathway
hasProperty
unknownQualifier
Mathematical Modelling Ontology Ordinary differential equation model
Curation status
Curated
Name Description Size Actions

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  • Model originally submitted by : Rahuman Sheriff
  • Submitted: 04-Oct-2017 14:17:35
  • Last Modified: 09-Nov-2018 16:04:32
Revisions
  • Version: 5 public model Download this version
    • Submitted on: 09-Nov-2018 16:04:32
    • Submitted by: Rahuman Sheriff
    • With comment: Minor update in model annotation.
  • Version: 3 public model Download this version
    • Submitted on: 04-Oct-2017 15:41:20
    • Submitted by: Rahuman Sheriff
    • With comment: Notes updated using online editor.
  • Version: 2 public model Download this version
    • Submitted on: 06-Oct-2017 10:21:07
    • Submitted by: Rahuman Sheriff
    • With comment: Current version of Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant
  • Version: 1 public model Download this version
    • Submitted on: 04-Oct-2017 14:17:35
    • Submitted by: Rahuman Sheriff
    • With comment: Original import of New Model
Curator's comment:
(added: 04 Oct 2017, 15:26:41, updated: 04 Oct 2017, 15:26:41)
Figure 7B of the reference publication has been reproduced. Simulations of the model were performed in COPASI 4.19 (Build 140). Figures are plotted using MatLab R2014b.