This is an SBML implementation the model of the substrate depletion oscillator (figure 2c) described in the article:
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Tyson JJ, Chen KC, Novak B. Curr Opin Cell Biol. 2003 Apr;15(2):221-31. PubmedID:12648679; DOI:10.1016/S0955-0674(03)00017-6;
Abstract:
The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.
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Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
- John J Tyson, Katherine C Chen, Bela Novak
- Current opinion in cell biology , 4/ 2003 , Volume 15 , Issue 2 , pages: 221-231 , PubMed ID: 12648679
- Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. tyson@vt.edu
- The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Lukas Endler
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