Wang1996_Synaptic_Inhibition_Two_Neuron

  public model
Model Identifier
BIOMD0000000302
Short description

This is a model of one presynaptic and one postsynaptic cell, as described in the article:
Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model.
Wang XJ, Buzsáki G. J Neurosci. 1996 Oct 15;16(20):6402-13. PMID:8815919;

Abstract:
Fast neuronal oscillations (gamma, 20-80 Hz) have been observed in the neocortex and hippocampus during behavioral arousal. Using computer simulations, we investigated the hypothesis that such rhythmic activity can emerge in a random network of interconnected GABAergic fast-spiking interneurons. Specific conditions for the population synchronization, on properties of single cells and the circuit, were identified. These include the following: (1) that the amplitude of spike afterhyperpolarization be above the GABAA synaptic reversal potential; (2) that the ratio between the synaptic decay time constant and the oscillation period be sufficiently large; (3) that the effects of heterogeneities be modest because of a steep frequency-current relationship of fast-spiking neurons. Furthermore, using a population coherence measure, based on coincident firings of neural pairs, it is demonstrated that large-scale network synchronization requires a critical (minimal) average number of synaptic contacts per cell, which is not sensitive to the network size. By changing the GABAA synaptic maximal conductance, synaptic decay time constant, or the mean external excitatory drive to the network, the neuronal firing frequencies were gradually and monotonically varied. By contrast, the network synchronization was found to be high only within a frequency band coinciding with the gamma (20-80 Hz) range. We conclude that the GABAA synaptic transmission provides a suitable mechanism for synchronized gamma oscillations in a sparsely connected network of fast-spiking interneurons. In turn, the interneuronal network can presumably maintain subthreshold oscillations in principal cell populations and serve to synchronize discharges of spatially distributed neurons.

The presynaptic and postsynaptic cell have identical parameters and the variables in each cell are identified by using _pre or _post as a postfix to their names. The presynaptic cell influences the postsynaptic one via the synapse (variables and parameters: I_syn, E_syn, g_syn, F, theta_syn, alpha, beta). The applied current to the presynaptic cell, I_app_pre, is set to 2 microA/cm2 for 10 ms as in figure 1C of the article. The dependence of the postsynaptic cell on directly applied current can be investigated in isolation by setting I_app_pre to 0 and altering I_app_post.

Originally created by libAntimony v1.4 (using libSBML 3.4.1)

Format
SBML (L2V4)
Related Publication
  • Gamma oscillation by synaptic inhibition in a hippocampal interneuronal network model.
  • Wang XJ, Buzsáki G
  • The Journal of neuroscience : the official journal of the Society for Neuroscience , 10/ 1996 , Volume 16 , pages: 6402-6413 , PubMed ID: 8815919
  • Physics Department, Brandeis University, Waltham, Massachusetts 02254, USA.
  • Fast neuronal oscillations (gamma, 20-80 Hz) have been observed in the neocortex and hippocampus during behavioral arousal. Using computer simulations, we investigated the hypothesis that such rhythmic activity can emerge in a random network of interconnected GABAergic fast-spiking interneurons. Specific conditions for the population synchronization, on properties of single cells and the circuit, were identified. These include the following: (1) that the amplitude of spike afterhyperpolarization be above the GABAA synaptic reversal potential; (2) that the ratio between the synaptic decay time constant and the oscillation period be sufficiently large; (3) that the effects of heterogeneities be modest because of a steep frequency-current relationship of fast-spiking neurons. Furthermore, using a population coherence measure, based on coincident firings of neural pairs, it is demonstrated that large-scale network synchronization requires a critical (minimal) average number of synaptic contacts per cell, which is not sensitive to the network size. By changing the GABAA synaptic maximal conductance, synaptic decay time constant, or the mean external excitatory drive to the network, the neuronal firing frequencies were gradually and monotonically varied. By contrast, the network synchronization was found to be high only within a frequency band coinciding with the gamma (20-80 Hz) range. We conclude that the GABAA synaptic transmission provides a suitable mechanism for synchronized gamma oscillations in a sparsely connected network of fast-spiking interneurons. In turn, the interneuronal network can presumably maintain subthreshold oscillations in principal cell populations and serve to synchronize discharges of spatially distributed neurons.
Contributors
Lukas Endler

Metadata information

is
BioModels Database MODEL1101240000
BioModels Database BIOMD0000000302
isDescribedBy
PubMed 8815919
hasTaxon
hasVersion
occursIn
Brenda Tissue Ontology hippocampus
Brenda Tissue Ontology neocortex

Curation status
Curated

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  • Model originally submitted by : Lukas Endler
  • Submitted: 24-Jan-2011 00:39:46
  • Last Modified: 08-Apr-2016 17:57:07
Revisions
  • Version: 2 public model Download this version
    • Submitted on: 08-Apr-2016 17:57:07
    • Submitted by: Lukas Endler
    • With comment: Current version of Wang1996_Synaptic_Inhibition_Two_Neuron
  • Version: 1 public model Download this version
    • Submitted on: 24-Jan-2011 00:39:46
    • Submitted by: Lukas Endler
    • With comment: Original import of Wang1996_Synaptic_Inhibition_Two_Neuron
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Curator's comment:
(added: 24 Jan 2011, 00:42:00, updated: 24 Jan 2011, 00:42:00)
Reproduction of figure 1 C of the original publication using Copasi 4.6.