The model reproduces the compartmental model for Ran transport as depicted in Fig 3 of the paper. Model reproduced using MathSBML.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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Systems analysis of Ran transport.
- Alicia E Smith, Boris M Slepchenko, James C Schaff, Leslie M Loew, Ian G Macara
- Science (New York, N.Y.) , 1/ 2002 , Volume 295 , Issue 5554 , pages: 488-491 , PubMed ID: 11799242
- Center for Cell Signaling, Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
- The separate components of nucleocytoplasmic transport have been well characterized, including the key regulatory role of Ran, a guanine nucleotide triphosphatase. However, the overall system behavior in intact cells is difficult to analyze because the dynamics of these components are interdependent. We used a combined experimental and computational approach to study Ran transport in vivo. The resulting model provides the first quantitative picture of Ran flux between the nuclear and cytoplasmic compartments in eukaryotic cells. The model predicts that the Ran exchange factor RCC1, and not the flux capacity of the nuclear pore complex (NPC), is the crucial regulator of steady-state flux across the NPC. Moreover, it provides the first estimate of the total in vivo flux (520 molecules per NPC per second and predicts that the transport system is robust.
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modeller: Harish Dharuri
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