Tyson1991 - Cell Cycle 6 var
View the 2006-10 Model of the Month entry for this modelMathematical model of the interactions of cdc2 and cyclin.
This model is described in the article:
Abstract:
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
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Modeling the cell division cycle: cdc2 and cyclin interactions.
- J J Tyson
- Proceedings of the National Academy of Sciences of the United States of America , 8/ 1991 , Volume 88 , Issue 16 , pages: 7328-7332 , PubMed ID: 1831270
- Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
- The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: administrator, Nicolas Le Novère
Metadata information
isDescribedBy (1 statement)
hasTaxon (1 statement)
isVersionOf (2 statements)
KEGG Pathway Cell cycle - yeast - Saccharomyces cerevisiae (budding yeast)
hasVersion (1 statement)
hasProperty (1 statement)
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