Tyson1991 - Cell Cycle 6 var
View the 2006-10 Model of the Month entry for this model
Mathematical model of the interactions of cdc2 and cyclin.
This model is described in the article:
Abstract:
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
This model is hosted on BioModels Database and identified by: BIOMD0000000005 .
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To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
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Modeling the cell division cycle: cdc2 and cyclin interactions.
- Tyson JJ
- Proceedings of the National Academy of Sciences of the United States of America , 8/ 1991 , Volume 88 , pages: 7328-7332 , PubMed ID: 1831270
- Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
- The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
Submitter of this revision: administrator
Modellers: administrator, Nicolas Le Novère
Metadata information
Gene Ontology mitotic cell cycle
Connected external resources
SBGN view in Newt Editor
| Name | Description | Size | Actions |
|---|---|---|---|
Model files |
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| BIOMD0000000005_url.xml | SBML L2V4 representation of Tyson1991 - Cell Cycle 6 var | 26.04 KB | Preview | Download |
Additional files |
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| BIOMD0000000005-biopax2.owl | Auto-generated BioPAX (Level 2) | 20.67 KB | Preview | Download |
| BIOMD0000000005-biopax3.owl | Auto-generated BioPAX (Level 3) | 29.48 KB | Preview | Download |
| BIOMD0000000005.m | Auto-generated Octave file | 5.66 KB | Preview | Download |
| BIOMD0000000005.pdf | Auto-generated PDF file | 177.40 KB | Preview | Download |
| BIOMD0000000005.png | Auto-generated Reaction graph (PNG) | 32.57 KB | Preview | Download |
| BIOMD0000000005.sci | Auto-generated Scilab file | 2.99 KB | Preview | Download |
| BIOMD0000000005.svg | Auto-generated Reaction graph (SVG) | 23.72 KB | Preview | Download |
| BIOMD0000000005.vcml | Auto-generated VCML file | 37.74 KB | Preview | Download |
| BIOMD0000000005.xpp | Auto-generated XPP file | 3.29 KB | Preview | Download |
| BIOMD0000000005_SED-ML.xml | This SED-ML file allows you to reproduce the curation result (Fig 3a), for example, by loading it into SED-ML Web Tools (http://sysbioapps.dyndns.org/SED-ML_Web_Tools/). | 2.06 KB | Preview | Download |
| BIOMD0000000005_manual.png | Manually generated Reaction graph (PNG) | 32.57 KB | Preview | Download |
| BIOMD0000000005_manual.svg | Manually generated Reaction graph (SVG) | 23.72 KB | Preview | Download |
| BIOMD0000000005_urn.xml | Auto-generated SBML file with URNs | 25.92 KB | Preview | Download |
- Model originally submitted by : Nicolas Le Novère
- Submitted: Sep 13, 2005 1:31:08 PM
- Last Modified: Dec 21, 2018 4:56:05 PM
Revisions
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Version: 3
- Submitted on: Dec 21, 2018 4:56:05 PM
- Submitted by: administrator
- With comment: Include the additional files provided by the submitter in the original submission: BIOMD0000000005_SED-ML.xml
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Version: 2
- Submitted on: May 16, 2013 3:40:43 PM
- Submitted by: Nicolas Le Novère
- With comment: Current version of Tyson1991 - Cell Cycle 6 var
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Version: 1
- Submitted on: Sep 13, 2005 1:31:08 PM
- Submitted by: Nicolas Le Novère
- With comment: Original import of Tyson1991_CellCycle_6var
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: Variable used inside SBML models
| Species | Initial Concentration/Amount |
|---|---|
| Y IPR006670 |
0.0 mol |
| M Cyclin-dependent kinase 1 ; IPR006670 |
0.0 mol |
| YP IPR006670 |
0.0 mol |
| CT Cyclin-dependent kinase 1 |
0.0 mol |
| C2 Cyclin-dependent kinase 1 |
0.0 mol |
| pM Cyclin-dependent kinase 1 ; IPR006670 |
0.25 mol |
| YT IPR006670 |
0.0 mol |
| Reactions | Rate | Parameters |
|---|---|---|
| EmptySet => Y | cell*k1aa | k1aa=0.015 |
| pM => M; CT | cell*pM*(k4prime+k4*(M/CT)^2) | k4=180.0; k4prime=0.018 |
| Y => EmptySet | cell*k2*Y | k2=0.0 |
| YP => EmptySet | cell*k7*YP | k7=0.6 |
| CT = C2+CP+M+pM | [] | [] |
| C2 => CP | cell*C2*k8notP | k8notP=1000000.0 |
| M => C2 + YP | cell*k6*M | k6=1.0 |
| M => pM | cell*k5notP*M | k5notP=0.0 |
| CP + Y => pM | cell*CP*k3*Y | k3=200.0 |
| YT = Y+YP+M+pM | [] | [] |
(added: 08 Feb 2010, 10:29:04, updated: 08 Feb 2010, 10:29:04)