EMDB EMD-9243

Single particle reconstruction
4.1Å resolution

Structure of full-length IP3R1 channel bound with Adenophostin A (composite)

Map released:
Last modified:
Overview of EMD-9243
Source organism: Rat [10116]
Fitted atomic model: 6mu1
Related EM entries by publication: EMD-9244, EMD-9245, EMD-9246, EMD-9247, EMD-9248
Primary publication:
Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating.
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res. 28 1158-1170 (2018)
PMID: 30470765

Function and Biology Details

Sample name: Inositol 1,4,5-trisphosphate receptor
Ligand: Adenophostin A
Proteins: Inositol 1,4,5-trisphosphate receptor, Inositol 1,4,5-trisphosphate receptor type 1

Experimental Information Details

Resolution: 4.1Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: RELION
Microscope: FEI TECNAI F30
Detector: GATAN K2 SUMMIT (4k x 4k)