EMDB EMD-8841

Single particle reconstruction
3.49Å resolution

Human TRPML1 channel structure in agonist-bound open conformation

Map released:
Last modified:
Overview of EMD-8841
Source organism: Homo sapiens [9606]
Fitted atomic model: 5wj9
Related EM entry by publication: EMD-8840
Primary publication:
Human TRPML1 channel structures in open and closed conformations.
Schmiege P, Fine M, Blobel G, Li X
Nature 550 366-370 (2017)
PMID: 29019983

Function and Biology Details

Sample name: TRPML1
Ligand: 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione
Proteins: TRPML1, Mucolipin-1

Experimental Information Details

Resolution: 3.49Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: FREALIGN
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)