EMDB EMD-8653

Single particle reconstruction
4.1Å resolution

Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein

Map released:
Last modified:
Overview of EMD-8653
Source organisms:
Fitted atomic model: 5vai
Primary publication:
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Nature 546 248-253 (2017)
PMID: 28538729

Function and Biology Details

Sample name: the activated glucagon-like peptide-1 receptor in complex with the heterotrimeric Gs protein
Proteins: the activated glucagon-like peptide-1 receptor in complex with the heterotrimeric Gs protein, Uncharacterized protein, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, nanobody 35

Experimental Information Details

Resolution: 4.1Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C1
Reconstruction software: RELION
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 SUMMIT (4k x 4k)