EMDB EMD-8192

Single particle reconstruction
3.8Å resolution

Cryo-EM structure of isocitrate dehydrogenase (IDH1)

Map released:
Last modified:
Overview of EMD-8192
Source organism: Homo sapiens [9606]
Fitted atomic model: 5k10
Related EM entries by publication: EMD-8191, EMD-8193, EMD-8194
Primary publication:
Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.
Merk A, Bartesaghi A, Banerjee S, Falconieri V, Rao P, Davis MI, Pragani R, Boxer MB, Earl LA, Milne JL, Subramaniam S
Cell 165 1698-1707 (2016)
PMID: 27238019

Function and Biology Details

Sample name: isocitrate dehydrogenase R132C mutant
Ligand: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Proteins: isocitrate dehydrogenase R132C mutant, Isocitrate dehydrogenase [NADP] cytoplasmic

Experimental Information Details

Resolution: 3.8Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C2
Microscope: FEI TITAN KRIOS
Detector: GATAN K2 QUANTUM (4k x 4k)