EMDB EMD-8117

Single particle reconstruction
2.95Å resolution

Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc

Map released:
Last modified:
Overview of EMD-8117
Source organisms:
Fitted atomic model: 5irx
Related EM entries by publication: EMD-8118, EMD-8119, EMD-8120
Primary publication:
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Gao Y, Cao E, Julius D, Cheng Y
Nature 534 347-351 (2016)
PMID: 27281200

Function and Biology Details

Sample name: TRPV1 ion channel in complex with DkTx and RTX
Ligands: (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, resiniferatoxin, (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate
Proteins: TRPV1 ion channel in complex with DkTx and RTX, Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a, Transient receptor potential cation channel subfamily V member 1, Tau-theraphotoxin-Hs1a

Experimental Information Details

Resolution: 2.95Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: RELION
Microscope: FEI POLARA 300
Detector: GATAN K2 SUMMIT (4k x 4k)