EMD-76979
Cryo-ET of mitochondrial membrane in direct interaction with alpha-synuclein exhibiting membrane morphological distortion
EMD-76979
Tomography
Deposition: 30/04/2026Map released: 27/05/2026
Last modified: 26/08/2026
Sample Organism:
Homo sapiens
Sample: Cell lysate from 3k M17D neuroblastoma cell line
Deposition Authors: Jaber N
,
Dai W
Sample: Cell lysate from 3k M17D neuroblastoma cell line
Deposition Authors: Jaber N
,
Dai W
Lipid droplets promote aberrant liquid-liquid phase separation of alpha-synuclein impairing energy homeostasis.
Cevallos J,
Eubanks E,
Jung S,
Huang Y,
Guadagno E,
Jaber N ,
Xia Y,
Wang J,
Wang H,
Suvvari NR,
Doshi A,
Ravinutala N,
Mosera A,
Hsu T,
Mody J,
Sacks B,
Narayan A,
Smith B,
Wang M,
Gottapu M,
Alnakhala H,
Ramalingam N,
Tripathi A,
Bartels T,
Dettmer U,
Shi Z,
Dai W ,
Kara E
(2026) EMBO Rep , 27 , 4299 - 4331
,
Xia Y,
Wang J,
Wang H,
Suvvari NR,
Doshi A,
Ravinutala N,
Mosera A,
Hsu T,
Mody J,
Sacks B,
Narayan A,
Smith B,
Wang M,
Gottapu M,
Alnakhala H,
Ramalingam N,
Tripathi A,
Bartels T,
Dettmer U,
Shi Z,
Dai W ,
Kara E
(2026) EMBO Rep , 27 , 4299 - 4331
Grant Support: