EMD-76291
Cryo-EM structure of human DDB1-CRBN-GSPT1 in complex with GT19630
EMD-76291
Single-particle2.9 Å
Deposition: 25/03/2026Map released: 26/08/2026
Last modified: 26/08/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of DDB1-CRBN with GSPT1
Fitted models: 12bp
Deposition Authors: Huang J
,
Chu HF ,
Tong L
Sample: Ternary complex of DDB1-CRBN with GSPT1
Fitted models: 12bp
Deposition Authors: Huang J
,
Chu HF ,
Tong L
Dual MYC and GSPT1 Protein Degrader for MYC-Driven Hematologic Malignancies.
Nishida Y,
Impedovo V ,
Ayoub E ,
Baran N ,
Scruggs DA,
Mizuno H,
Khazaei S,
Ostermann LB ,
Kamachi K ,
Zhang L,
Ishizawa J,
Singh S ,
Bedoy AD ,
Mak PY,
Carter BZ,
Sugihara E ,
Takimoto T ,
Tong Y,
Yan H,
Chen D,
Huang J ,
Chu HF ,
Tong L ,
Ahmed Z ,
Namjoshi S,
Tainer J,
Gagea M,
Huynh T,
Maiti A ,
Sasaki K ,
Cuglievan B,
Boettcher S ,
Haferlach T,
Tiziani S ,
Ma L,
Andreeff M
(2026) Blood
,
Ayoub E ,
Baran N ,
Scruggs DA,
Mizuno H,
Khazaei S,
Ostermann LB ,
Kamachi K ,
Zhang L,
Ishizawa J,
Singh S ,
Bedoy AD ,
Mak PY,
Carter BZ,
Sugihara E ,
Takimoto T ,
Tong Y,
Yan H,
Chen D,
Huang J ,
Chu HF ,
Tong L ,
Ahmed Z ,
Namjoshi S,
Tainer J,
Gagea M,
Huynh T,
Maiti A ,
Sasaki K ,
Cuglievan B,
Boettcher S ,
Haferlach T,
Tiziani S ,
Ma L,
Andreeff M
(2026) Blood
Grant Support:
- Other private: (China)