EMD-75840
Cryo-EM structure of CRBN in complex with HBS1L and TNG-4857 (focused refinement)
EMD-75840
Single-particle2.6 Å
Deposition: 05/03/2026Map released: 06/05/2026
Last modified: 16/09/2026
Sample Organism:
Homo sapiens
Sample: Dimeric assembly of the ternary complex of CRBN/DDB1 plus HBS1L and TNG-4857
Fitted models: 11mr
Deposition Authors: Whittington DA
Sample: Dimeric assembly of the ternary complex of CRBN/DDB1 plus HBS1L and TNG-4857
Fitted models: 11mr
Deposition Authors: Whittington DA
TNG961 Is a Selective Oral HBS1L Molecular Glue Degrader for the Treatment of FOCAD-Deleted Cancers.
Nicholson HE ,
Whittington DA ,
Bruzzese FJ ,
Lazarides K ,
Martires LCM ,
Tonini MR ,
Jenkins HN ,
Zhang M ,
Shahagadkar P ,
Pratt CB ,
Briggs KJ ,
McCarren P ,
Tsai AW,
Bandi M ,
Min C ,
Huang A ,
Zhang H ,
Meier SR ,
Shen B ,
Yu Y ,
Liang C ,
Liu Y ,
Teng T ,
Zhang J ,
Crystal A ,
Mallender WD ,
Wu XE ,
Maxwell JP ,
Andersen JN
(2026) Cancer Discov , 16 , 1884 - 1902
,
Whittington DA ,
Bruzzese FJ ,
Lazarides K ,
Martires LCM ,
Tonini MR ,
Jenkins HN ,
Zhang M ,
Shahagadkar P ,
Pratt CB ,
Briggs KJ ,
McCarren P ,
Tsai AW,
Bandi M ,
Min C ,
Huang A ,
Zhang H ,
Meier SR ,
Shen B ,
Yu Y ,
Liang C ,
Liu Y ,
Teng T ,
Zhang J ,
Crystal A ,
Mallender WD ,
Wu XE ,
Maxwell JP ,
Andersen JN
(2026) Cancer Discov , 16 , 1884 - 1902
Grant Support:
- Other private: (United States)