EMD-75588

Single-particle
3.0 Å
EMD-75588
3D View Gallery
Deposition: 13/02/2026
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75588

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-11ak summary report (pdf.gz) Map-11ak FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of a bovine CLC-K S68N/R355K chloride channel with inhibitor M-BIM15

EMD-75588

Single-particle
3.0 Å
EMD-75588
3D View Gallery
Deposition: 13/02/2026
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Bos taurus
Sample: bovine CLC-K S68N/R355K chloride channel with inhibitor BIM15
Fitted models: 11ak

Deposition Authors: Chien C-T, Chiu W, Maduke M
Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels
Chien CT, Sobecks-Doherty BL, Powers AS, Das A, Kreiter J, Barry CN, Chen M, Hinman A, Petrakian CF, Williams B, Wood CAP, Xu M, Dror RO, Chiu W, Maduke M
(2026) PNAS , 123
DOI: doi:10.1073/pnas.2605886123
ISSN: 1091-6490
ASTM: PNASA6