EMD-75196

Helical reconstruction
3.2 Å
EMD-75196
3D View Gallery
Deposition: 21/01/2026
Map released: 11/03/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75196
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 10ik summary report (pdf.gz) Map and 10ik FULL report (pdf.gz)
EMICSS annotations (xml)

S305I Frontotemporal Lobar Degeneration (FTLD) type II tau filament

EMD-75196

Helical reconstruction
3.2 Å
EMD-75196
3D View Gallery
Deposition: 21/01/2026
Map released: 11/03/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Filaments purified S305I FTLD individual brain tissue
Fitted models: 10ik

Deposition Authors: Pan HS, Merz GE, Tse E, Southworth DR
Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation.
Pan HS, Merz GE, Li AN, Le MQ, Jo H, Quddus A, Yung A, Kormos RC, Melo AA, Ramos EM, Lago AL, Spina S, Grinberg LT, Rosen HJ, Tse E, Gorno-Tempini ML, DeGrado WF, Seeley WW, Southworth DR
(2026) bioRxiv
PUBMED: 41726928
DOI: doi:10.64898/2026.02.12.705620
ISSN: 2692-8205