EMD-75195
S305I Frontotemporal Lobar Degeneration (FTLD) type I tau filament
EMD-75195
Helical reconstruction3.1 Å
Deposition: 21/01/2026Map released: 11/03/2026
Last modified: 11/03/2026
Sample Organism:
Homo sapiens
Sample: Filaments purified S305I FTLD individual brain tissue
Fitted models: 10ij
Deposition Authors: Pan HS
,
Merz GE ,
Tse E ,
Southworth DR
Sample: Filaments purified S305I FTLD individual brain tissue
Fitted models: 10ij
Deposition Authors: Pan HS
,
Merz GE ,
Tse E ,
Southworth DR
Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation.
Pan HS ,
Merz GE ,
Li AN ,
Le MQ ,
Jo H ,
Quddus A,
Yung A,
Kormos RC ,
Melo AA ,
Ramos EM ,
Lago AL,
Spina S ,
Grinberg LT ,
Rosen HJ ,
Tse E ,
Gorno-Tempini ML ,
DeGrado WF ,
Seeley WW ,
Southworth DR
(2026) bioRxiv
,
Merz GE ,
Li AN ,
Le MQ ,
Jo H ,
Quddus A,
Yung A,
Kormos RC ,
Melo AA ,
Ramos EM ,
Lago AL,
Spina S ,
Grinberg LT ,
Rosen HJ ,
Tse E ,
Gorno-Tempini ML ,
DeGrado WF ,
Seeley WW ,
Southworth DR
(2026) bioRxiv
Grant Support:
- Other private: A2023019F
- National Institutes of Health/National Institute on Aging (NIH/NIA): P30AG062422 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): P01AG019724 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): U01AG057195 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): U19AG063911 (United States)
- Other private:
- Other private:
- National Institutes of Health/National Institute on Aging (NIH/NIA): U19: AG063911 (United States)
- Other private: U54 NS092089
- Other private: U01 AG045390
- National Institutes of Health/National Institute on Aging (NIH/NIA): P01 AG019724 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): P30 AG062422 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): U24 AG21886) (United States)