EMD-74451
Cryo-EM structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in complex with APPB, composite map
EMD-74451
Single-particle2.9 Å
Deposition: 14/12/2025Map released: 04/02/2026
Last modified: 04/02/2026
Sample Organism:
Homo sapiens
Sample: Human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in complex with APPB
Fitted models: 9znn
Deposition Authors: Kirsh JM
,
Ochoa JM ,
Soroush-Pejrimovsky MT ,
Kaudeer BY ,
Clemons WM
Sample: Human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in complex with APPB
Fitted models: 9znn
Deposition Authors: Kirsh JM
,
Ochoa JM ,
Soroush-Pejrimovsky MT ,
Kaudeer BY ,
Clemons WM
Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics.
Kaudeer BY ,
Kirsh JM ,
Mitachi K ,
Ochoa JM ,
Soroush-Pejrimovsky MT ,
Li YE ,
Nguyen VN ,
Kurosu M ,
Clemons Jr WM
(2025) bioRxiv
,
Kirsh JM ,
Mitachi K ,
Ochoa JM ,
Soroush-Pejrimovsky MT ,
Li YE ,
Nguyen VN ,
Kurosu M ,
Clemons Jr WM
(2025) bioRxiv
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM114611 (United States)
- The G. Harold and Leila Y. Mathers Foundation: (United States)
- Chan Zuckerberg Initiative: (United States)