EMD-74399

Helical reconstruction
2.9 Å
EMD-74399
3D View Gallery
Deposition: 08/12/2025
Map released: 15/04/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74399

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zld summary report (pdf.gz) Map-9zld FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of hepatic amyloid fibril from a variant ATTRV122delta, single filament morphology

EMD-74399

Helical reconstruction
2.9 Å
EMD-74399
3D View Gallery
Deposition: 08/12/2025
Map released: 15/04/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: fibrils of ATTRV122delta
Fitted models: 9zld

Deposition Authors: Nguyen BA , Ahmed Y, Saelices L
Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations.
Nguyen BA , Fernandez-Ramirez MDC , Bassett P , Singh V , Singh P , Pekala M, Villalon L, Ahmed Y, Lemoff A , Evers B, Lopez C, Kluve-Beckerman B, Saelices L
(2026) Nat Commun , 17
PUBMED: 41991931
DOI: doi:10.1038/s41467-026-72150-z
ISSN: 2041-1723