EMD-74330

Single-particle
6.35 Å
EMD-74330
3D View Gallery
Deposition: 05/12/2025
Map released: 22/04/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74330

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

SMO/PKA-C complex, mixed prior to grid preparation

EMD-74330

Single-particle
6.35 Å
EMD-74330
3D View Gallery
Deposition: 05/12/2025
Map released: 22/04/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Bos taurus
Sample: SMO/PKA-C

Deposition Authors: Liu G , Myers BR
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.
Steiner WP, Iverson N, Liu G , Venkatakrishnan V, Wu J, Stepniewski TM, Michaelson Z, Brockel JW, Zhu JF, Bruystens JGH, Lee A, Nelson I, Bertinetti D, Arveseth CD, Tan G, Spaltenstein P, Xu J, Huttenhain R, Kay MS, Herberg FW, Cao E, Selent J, Anand GS, Dunbrack Jr RL, Taylor SS, Myers BR
(2026) Nat Struct Mol Biol , 33 , 795 - 809
PUBMED: 42062515
DOI: doi:10.1038/s41594-026-01800-z
ISSN: 1545-9985