EMD-74296

Single-particle
2.2 Å
EMD-74296
3D View Gallery
Deposition: 04/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74296

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Focused map of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ADP, 4-chloro-m-cresol, caffeine, and Mg2+ (NSol mask)

EMD-74296

Single-particle
2.2 Å
EMD-74296
3D View Gallery
Deposition: 04/12/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Oryctolagus cuniculus
Sample: ryanodine receptor 1 complexed with calmodulin and calstabin 2

Deposition Authors: Kim K , Clarke OB
Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
Kim K , Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-76519-y
ISSN: 2041-1723