EMD-74113
Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1B2
EMD-74113
Single-particle3.17 Å
Deposition: 30/11/2025Map released: 04/03/2026
Last modified: 22/07/2026
Sample Organism:
Homo sapiens,
artificial sequences
Sample: Nucleosome-VHH complex containing single-chain antibody 1B2
Fitted models: 9zen
Deposition Authors: Chakraborty U
,
Saccone EC ,
Becerra GC ,
Khan LF ,
Arslanovic N ,
Aguilar R ,
Gloor SL ,
Hunt SR ,
Folkwein HJ ,
Husby NL,
Maier KE ,
Marunde MR ,
Schomburg NK ,
Vaidya A ,
Cowles MW ,
Venters BJ ,
Kassavetis G ,
Sun Z-W ,
Kadonaga JT ,
Armache J-P,
Keogh M-C,
Tyler JK
Sample: Nucleosome-VHH complex containing single-chain antibody 1B2
Fitted models: 9zen
Deposition Authors: Chakraborty U
,
Saccone EC ,
Becerra GC ,
Khan LF ,
Arslanovic N ,
Aguilar R ,
Gloor SL ,
Hunt SR ,
Folkwein HJ ,
Husby NL,
Maier KE ,
Marunde MR ,
Schomburg NK ,
Vaidya A ,
Cowles MW ,
Venters BJ ,
Kassavetis G ,
Sun Z-W ,
Kadonaga JT ,
Armache J-P,
Keogh M-C,
Tyler JK
Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.
Chakraborty U ,
Saccone EC ,
Cruz-Becerra G,
Khan LF ,
Arslanovic N ,
Aguilar R ,
Gloor SL ,
Hunt SR ,
Folkwein HJ ,
Husby NL,
Maier KE ,
Marunde MR ,
Schomburg NK ,
Vaidya A ,
Cowles MW ,
Venters BJ ,
Kassavetis G ,
Sun ZW,
Kadonaga JT ,
Armache JP,
Keogh MC ,
Tyler JK
(2026) Nucleic Acids Res , 54
,
Saccone EC ,
Cruz-Becerra G,
Khan LF ,
Arslanovic N ,
Aguilar R ,
Gloor SL ,
Hunt SR ,
Folkwein HJ ,
Husby NL,
Maier KE ,
Marunde MR ,
Schomburg NK ,
Vaidya A ,
Cowles MW ,
Venters BJ ,
Kassavetis G ,
Sun ZW,
Kadonaga JT ,
Armache JP,
Keogh MC ,
Tyler JK
(2026) Nucleic Acids Res , 54
Grant Support:
- National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI): R44HG010640 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R44GM117683 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R44GM136172 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R44CA212733 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R43GM134834 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM149780 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM139816 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01CA95641 (United States)