EMD-73991
Cryo-EM structure of human apo mTORC2
EMD-73991
Single-particle3.2 Å
Deposition: 20/11/2025Map released: 15/04/2026
Last modified: 15/04/2026
Sample Organism:
Homo sapiens
Sample: mTORC2 apo
Fitted models: 9zbj
Deposition Authors: Wranik M, Lee JM, Rogala KB
Sample: mTORC2 apo
Fitted models: 9zbj
Deposition Authors: Wranik M, Lee JM, Rogala KB
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.
Taylor MS ,
Chen M ,
Hancock M,
Wranik M,
Miller BD ,
O'Meara TR ,
Palanski BA ,
Ficarro SB ,
Groendyke BJ,
Xiang Y ,
Kondo KT ,
Linde-Garelli KY ,
Lee MJ ,
Mondal D ,
Freund D ,
Congreve S ,
Matas K ,
Hennink M ,
Xibinaku K ,
Valenstein ML ,
van Eeuwen T ,
Marto JA ,
Sali A ,
Shi Y ,
Gray NS ,
Sabatini DM ,
Chu N ,
Rogala KB ,
Cole PA
(2026) Science , 391 , eadv7111 - eadv7111
,
Chen M ,
Hancock M,
Wranik M,
Miller BD ,
O'Meara TR ,
Palanski BA ,
Ficarro SB ,
Groendyke BJ,
Xiang Y ,
Kondo KT ,
Linde-Garelli KY ,
Lee MJ ,
Mondal D ,
Freund D ,
Congreve S ,
Matas K ,
Hennink M ,
Xibinaku K ,
Valenstein ML ,
van Eeuwen T ,
Marto JA ,
Sali A ,
Shi Y ,
Gray NS ,
Sabatini DM ,
Chu N ,
Rogala KB ,
Cole PA
(2026) Science , 391 , eadv7111 - eadv7111
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): K99/R00 CA255926 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R35 GM150935 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): P30 CA124435 (United States)
- Other private: Shmunis Family Innovation Award (United States)
- Other private: Bridging Excellence Fellowship (Germany)
- Other private: (United States)