EMD-73821
HECT domain of NEDD4-2 complex with a targeted nanobody, nb.C11
EMD-73821
Single-particle3.06 Å
Deposition: 12/11/2025Map released: 17/12/2025
Last modified: 28/01/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: HECT domain of NEDD4-2
Fitted models: 9z5q
Deposition Authors: Afriyie E
,
Clarke OB
Sample: HECT domain of NEDD4-2
Fitted models: 9z5q
Deposition Authors: Afriyie E
,
Clarke OB
Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies.
Darko-Boateng A ,
Afriyie E ,
Morgenstern TJ,
Shanmugam SK ,
Zou X,
Laloudakis YD,
Choudhury P,
Desai M,
Kass RS,
Vallese F,
Clarke OB ,
Colecraft HM
(2025) Nat Commun , 17 , 378 - 378
,
Afriyie E ,
Morgenstern TJ,
Shanmugam SK ,
Zou X,
Laloudakis YD,
Choudhury P,
Desai M,
Kass RS,
Vallese F,
Clarke OB ,
Colecraft HM
(2025) Nat Commun , 17 , 378 - 378
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): RO1-HL121253 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): RO1-HL142111 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): R01-NS126850 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): P01-HL164319 (United States)
- American Heart Association: 20PRE35210815 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): F31 DK118866 (United States)
- American Heart Association: POST1019343 (United States)