EMD-73759

Single-particle
2.83 Å
EMD-73759
3D View Gallery
Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73759
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9z21 summary report (pdf.gz) Map and 9z21 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human TRPM4 channel in complex with calcium and NC1 at 37 degrees Celsius (consensus)

EMD-73759

Single-particle
2.83 Å
EMD-73759
3D View Gallery
Deposition: 04/11/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human TRPM4 channel in complex with calcium and NC1 at 37 degrees Celsius
Fitted models: 9z21

Deposition Authors: Hu J, Lu W, Du J
Temperature and intrinsic Ca 2+ reshape TRPM4 pharmacology.
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O'Dea G, Sheng J, Du J, Lu W
(2026) Nat Struct Mol Biol
PUBMED: 42265346
DOI: doi:10.1038/s41594-026-01818-3
ISSN: 1545-9985