EMD-73510

Single-particle
2.6 Å
EMD-73510
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Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73510
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yuz summary report (pdf.gz) Map and 9yuz FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the human 20S proteasome in complex with a beta5-selective covalent syringolin analogue inhibitor.

EMD-73510

Single-particle
2.6 Å
EMD-73510
3D View Gallery
Deposition: 23/10/2025
Map released: 15/04/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human 20S proteasome
Fitted models: 9yuz

Deposition Authors: Yan NL, Gu X , Fajtova P, Tse E, Melo A, Southworth DR , O'Donoghue A, Sello JK , Gestwicki JE
An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome.
Gu X , Fajtova P, Yan NL, Saxena A, Fei F , Zhu J , Tse E, Melo A, Yoo E , Buchwald NH, Southworth DR , Bogyo M , Derisi JL, Gestwicki JE , O'Donoghue AJ, Sello JK
(2026) J Med Chem
PUBMED: 41921688
DOI: doi:10.1021/acs.jmedchem.5c03223
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: