EMD-73492

Single-particle
4.35 Å
EMD-73492
3D View Gallery
Deposition: 21/10/2025
Map released: 19/08/2026
Last modified: 19/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73492

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Focused refinement map on LRRK2 bound to GMPPNP (inactive) Resolve EM

EMD-73492

Single-particle
4.35 Å
EMD-73492
3D View Gallery
Deposition: 21/10/2025
Map released: 19/08/2026
Last modified: 19/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Leucine Rich repeat kinase 2 bound to GMP-PNP

Deposition Authors: Villagran Suarez A, Bodrug T, Leschziner A
The structural basis for LRRK2's activation and autoinhibition
Villagran Suarez A, Hatch KS, Bodrug T, Gai W, Surridge KJ, Moussikhina E, Nguyen KH, Sanz-Murillo M, Callahan R, Xiong E, Ramos D, Zhu L, Dederer V, Mathea S, Iwasa J, Knapp S, Shokat KM, Reck-Peterson SL, Leschziner AE
(2026) Cell
DOI: doi:10.1016/j.cell.2026.07.027
ISSN: 0092-8674
ASTM: CELLB5
Grant Support: